Publications by authors named "Alexander Sorets"

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Developing Topics.
Adam Abdulrahman, Nora Francini, Alexander Ligocki, Alexander Sorets, Andrew Kjar

Alzheimers Dement· December 2025

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Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.
Alexander G Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Sarah Lyons

J Control Release· November 2025

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siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.
Juan M Colazo, Megan C Keech, Veeraj Shah, Ella N Hoogenboezem, Justin H Lo, Alexander G Sorets

Nat Biomed Eng· August 2025

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Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
Alexander G Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Adam M Abdulrahman

Nucleic Acids Res· June 2025

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IQGAP2 regulates blood-brain barrier immune dynamics.
Ketaki A Katdare, Andrew Kjar, Natasha M O'Brown, Emma H Neal, Alexander G Sorets

iScience· March 2025

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Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.
Alexander G Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Sarah Lyons

bioRxiv· March 2025

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Fabrication of endothelialized capillary-like microchannel networks using sacrificial thermoresponsive microfibers.
John A Rector Iv, Lucas McBride, Callie M Weber, Kira Grossman, Alexander Sorets

Biofabrication· November 2024

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Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells.
Justin H Lo, Eva F Gbur, Nora Francini, Jinqi Ma, Alexander G Sorets

bioRxiv· October 2024

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Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Alexander G Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Adam M Abdulrahman

bioRxiv· September 2024

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IQGAP2 regulates blood-brain barrier immune dynamics.
Ketaki A Katdare, Andrew Kjar, Natasha M O'Brown, Emma H Neal, Alexander G Sorets

bioRxiv· April 2024

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Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis.
Juan M Colazo, Ella N Hoogenboezem, Megan C Keech, Nora Francini, Veeraj Shah, Alexander G Sorets

bioRxiv· December 2023

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Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G Sorets, Suil Kim

Nat Commun· November 2022

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A microengineered Brain-Chip to model neuroinflammation in humans.
Iosif Pediaditakis, Konstantia R Kodella, Dimitris V Manatakis, Christopher Y Le, Sonalee Barthakur, Alexander Sorets

iScience· August 2022

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Albumin-Binding Aptamer Chimeras for Improved siRNA Bioavailability.
Jonah C Rosch, Ella N Hoogenboezem, Alexander G Sorets, Craig L Duvall, Ethan S Lippmann

Cell Mol Bioeng· April 2022

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Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice.
Sam Hana, Michael Peterson, Helen McLaughlin, Eric Marshall, Attila J Fabian, Alexander Sorets

Gene Ther· November 2021

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Caveolae-Mediated Transport at the Injured Blood-Brain Barrier as an Underexplored Pathway for Central Nervous System Drug Delivery.
Alexander G Sorets, Jonah C Rosch, Craig L Duvall, Ethan S Lippmann

Curr Opin Chem Eng· December 2020

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