Publications by authors named "Alexander Spasov"

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Azolo[5',1',2,3]pyrimido[5,4-e]tetrazolo[1,5-c]pyrimidines as dual-action antiglycators and α-glucosidase inhibitors.
Grigoriy V Urakov, Konstantin V Savateev, Pavel A Slepukhin, Vladimir L Rusinov, Umida M Ibragimova, Alexander A Spasov

Bioorg Med Chem Lett· December 2025

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Synthesis of novel 4/5-substituted 3-arylidene-2-oxindole derivatives and their biological evaluation as NQO2 ligands and NLRP3 downregulators.
Elena N Bezsonova, Meriam Dubar, Daria D Melekhina, Mariia A Salykina, Ivan V Boichenko, Alexander A Spasov

Bioorg Med Chem Lett· December 2025

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Discovery of Novel 2-Oxindoles as Compounds with Antiglaucoma Activity.
Roman O Eremeev, Alexander M Efremov, Daria V Zakharova, Olga V Beznos, Elena V Sokolova, Alexander A Spasov

ChemMedChem· May 2025

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Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone-Imidazole Ligands.
Ilya A Shutkov, Nikolai A Melnichuk, Sofya A Ovakimyan, Dmitrii M Mazur, Nataliya E Borisova, Alexander A Spasov

Int J Mol Sci· May 2025

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Spacered With Tetrazole Oleanolic and Ursolic Indolo-Acids Are Strong Inhibitors of α-Glucosidase.
Anastasiya V Petrova, Denis A Babkov, Roman D Danilov, Elena V Sokolova, Oxana B Kazakova, Alexander A Spasov

Chem Biol Drug Des· March 2025

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A Novel Dipterocarpol Derivative That Targets Alpha-Glucosidase and NLRP3 Inflammasome Activity for Treatment of Diabetes Mellitus.
Roman D Danilov, Irina E Smirnova, Zarema I Galimova, Elena V Sokolova, Andrey V Lukyanov, Alexander A Spasov

Chem Biodivers· January 2025

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Ruthenium complexes with abiraterone acetate as antiproliferative agents.
Anastasia A Antonets, Ekaterina V Spitsyna, Vladimir Yu Tyurin, Dmitrii M Mazur, Dmitry S Yakovlev, Alexander A Spasov

J Inorg Biochem· January 2025

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Directed Design, Screening and Antiglycation Activity for 3-Substituted Thiazolium Derivatives, New Analogs of Alagebrium.
Olga N Zhukovskaya, Alexandra A Kolodina, Roman Litvinov, Umida Ibragimova, Nikita Valuisky, Alexander A Spasov

Chem Biol Drug Des· October 2024

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Synthesis and antiglycation activity of 3-phenacyl substituted thiazolium salts, new analogs of Alagebrium.
Alexander Ozerov, Darya Merezhkina, Fedor I Zubkov, Roman Litvinov, Umida Ibragimova, Alexander Spasov

Chem Biol Drug Des· January 2024

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Novel Substituted Azoloazines with Anticoagulant Activity.
Alexander A Spasov, Olga V Fedorova, Nikolay A Rasputin, Irina G Ovchinnikova, Rashida I Ishmetova

Int J Mol Sci· October 2023

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3-Arylidene-2-oxindoles as GSK3β inhibitors and anti-thrombotic agents.
Denis Babkov, Elena Bezsonova, Viktor Sirotenko, Elias Othman, Vladlen Klochkov, Alexander Spasov

Bioorg Med Chem Lett· May 2023

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Consensus Ensemble Multitarget Neural Network Model of Anxiolytic Activity of Chemical Compounds and Its Use for Multitarget Pharmacophore Design.
Pavel M Vassiliev, Dmitriy V Maltsev, Alexander A Spasov, Maxim A Perfilev, Maria O Skripka

Pharmaceuticals (Basel)· May 2023

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Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity.
Denis A Babkov, Olga N Zhukovskaya, Anastasia A Brigadirova, Diana R Prilepskaya, Alexandra A Kolodina, Alexander A Spasov

Chem Biol Drug Des· April 2023

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New Organometallic Ru(II) Compounds with Lonidamine Motif as Antitumor Agents.
Ilya A Shutkov, Yulia N Okulova, Dmitrii M Mazur, Nikolai A Melnichuk, Denis A Babkov, Alexander A Spasov

Pharmaceutics· April 2023

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Amino Derivatives of Diaryl Pyrimidines and Azolopyrimidines as Protective Agents against LPS-Induced Acute Lung Injury.
Alexander Spasov, Irina Ovchinnikova, Olga Fedorova, Yulia Titova, Denis Babkov

Molecules· January 2023

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3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors.
Natalia A Lozinskaya, Elena N Bezsonova, Meriam Dubar, Daria D Melekhina, Daniil R Bazanov, Alexander A Spasov

Molecules· January 2023

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New Molecules of Diterpene Origin with Inhibitory Properties toward α-Glucosidase.
Elena Tretyakova, Irina Smirnova, Oxana Kazakova, Ha Thi Thu Nguyen, Alina Shevchenko, Alexander Spasov

Int J Mol Sci· November 2022

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Design, Synthesis and Pharmacological Evaluation of Novel C,C-Quinoxaline Derivatives as Promising Anxiolytic Agents.
Dmitriy V Maltsev, Maria O Skripka, Alexander A Spasov, Pavel M Vassiliev, Maxim A Perfiliev

Int J Mol Sci· November 2022

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Cytotoxic and Luminescent Properties of Novel Organotin Complexes with Chelating Antioxidant Ligand.
Evgeny Nikitin, Ekaterina Mironova, Dmitry Shpakovsky, Yulia Gracheva, Daniil Koshelev, Alexander Spasov

Molecules· November 2022

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Guanidine Derivatives of Quinazoline-2,4(1,3)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents.
Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko

Life (Basel)· October 2022

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Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A adenosine receptor agonists.
Maria Ya Berzina, Barbara Z Eletskaya, Alexei L Kayushin, Elena V Dorofeeva, Olga I Lutonina, Alexander A Spasov

Bioorg Chem· September 2022

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Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety.
Vladimir Burmistrov, Christophe Morisseau, Denis A Babkov, Tatiana Golubeva, Dmitry Pitushkin, Alexander A Spasov

Int J Mol Sci· September 2022

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CK2 Inhibition and Antitumor Activity of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines.
Daniil N Lyapustin, Svetlana K Kotovskaya, Ilya I Butorin, Evgeny N Ulomsky, Vladimir L Rusinov, Alexander A Spasov

Molecules· August 2022

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Discovery of Nitro-azolo[1,5-]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury.
Alexander Spasov, Vadim Kosolapov, Denis Babkov, Vladlen Klochkov, Elena Sokolova

Pharmaceuticals (Basel)· April 2022

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Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects.
Alexey Sarapultsev, Pavel Vassiliev, Daniil Grinchii, Alexander Kiss, Mojmir Mach, Alexander Spasov

Int J Mol Sci· December 2021

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