Publications by authors named "Alexander Zlatkov"

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Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening.
Emilio Mateev, Samir Chtita, Ekaterina Pavlova, Ali Irfan, Diana Tzankova, Alexander Zlatkov

Pharmaceuticals (Basel)· November 2025

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Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson's Disease.
Maya Georgieva, Martin Sharkov, Emilio Mateev, Diana Tzankova, Georgi Popov, Alexander Zlatkov

Molecules· July 2025

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Antioxidant and Neuroprotective Properties of Selected Pyrrole-Containing Azomethine Compounds in Neurotoxicity Models In Vitro.
Denitsa Stefanova, Alime Garip, Emilio Mateev, Magdalena Kondeva-Burdina, Yordan Yordanov, Alexander Zlatkov

Int J Mol Sci· April 2025

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Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer's Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation.
Emilio Mateev, Valentin Karatchobanov, Marjano Dedja, Konstantinos Diamantakos, Alexandrina Mateeva, Alexander Zlatkov

Pharmaceuticals (Basel)· September 2024

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Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring.
Maya Georgieva, Emilio Mateev, Iva Valkova, Hristina Kuteva, Diana Tzankova, Alexander Zlatkov

Molecules· September 2024

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In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes.
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Alexander Zlatkov

Molecules· March 2024

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Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines.
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Alexander Zlatkov

Pharmaceuticals (Basel)· August 2023

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Repurposing of FDA-approved drugs as dual-acting MAO-B and AChE inhibitors against Alzheimer's disease: An in silico and in vitro study.
Emilio Mateev, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov

J Mol Graph Model· July 2023

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Structure-Based Design of Novel MAO-B Inhibitors: A Review.
Emilio Mateev, Maya Georgieva, Alexandrina Mateeva, Alexander Zlatkov, Shaban Ahmad

Molecules· June 2023

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and Determination of Antiproliferative Activity of Series N-Pyrrolyl Hydrazide-Hydrazones and Evaluation of their Effects on Isolated Rat Mycrosomes and Hepatocytes.
Maya Georgieva, Diana Tzankova, Emilio Mateev, Borislav Angelov, Magdalena Kondeva-Burdina, Alexander Zlatkov

Anticancer Agents Med Chem· March 2023

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Identification of Novel SARS-CoV-2 Main Protease and Nonstructural Protein 13 (nsp13) Inhibitors through Consensus Docking and Free Binding Energy Calculations.
Emilio Mateev, Maya Georgieva, Alexander Zlatkov

Comb Chem High Throughput Screen· March 2023

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Simultaneous analysis of water-soluble and fat-soluble vitamins through RP-HPLC/DAD in food supplements and brewer's yeast.
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Lily Peikova, Silvia Guncheva, Alexander Zlatkov

Heliyon· January 2023

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Quantitative Structure-Neurotoxicity Assessment and In Vitro Evaluation of Neuroprotective and MAO-B Inhibitory Activities of Series '-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides.
Magdalena Kondeva-Burdina, Javor Mitkov, Iva Valkova, Lily Peikova, Maya Georgieva, Alexander Zlatkov

Molecules· August 2022

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Pyrrole as an Important Scaffold of Anticancer Drugs: Recent Advances.
Emilio Mateev, Maya Georgieva, Alexander Zlatkov

J Pharm Pharm Sci· March 2022

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Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In-vitro Neuroprotective and MAO-B Inhibitory Activities.
Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Alexander Zlatkov

Med Chem· November 2020

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Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson`s Disease.
Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov

Curr Med Chem· July 2020

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Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects.
Lily Andonova, Iva Valkova, Dimitrina Zheleva-Dimitrova, Maya Georgieva, Georgi Momekov, Alexander Zlatkov

Anticancer Agents Med Chem· February 2020

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Preliminary evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines.
Magdalena Kondeva-Burdina, Maya Georgieva, Alexandra Kasabova-Angelova, Virginia Tzankova, Alexander Zlatkov

Neural Regen Res· June 2019

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Determination of the Antiproliferative Activity of New Theobromine Derivatives and Evaluation of Their In Vitro Hepatotoxic Effects.
Maya Georgieva, Magdalena Kondeva-Burdina, Javor Mitkov, Virginia Tzankova, Georgi Momekov, Alexander Zlatkov

Anticancer Agents Med Chem· June 2017

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Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4.
Lily Andonova, Dimitrina Zheleva-Dimitrova, Maya Georgieva, Alexander Zlatkov

Biotechnol Biotechnol Equip· November 2014

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Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid.
Javor Mitkov, Nikolai Danchev, Irina Nikolova, Alexander Zlatkov

Acta Pharm· September 2007

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