Publications by authors named "Alexandr Kornev"

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LSP-MD: A Fast Computational Method to Study Allostery Driven by Thermal Vibrations.
Alexandr P Kornev

J Chem Theory Comput· September 2025

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Local and distal changes in dynamics are caused by an L205R Cushing's syndrome mutant in PRKACA.
Anagha Kalle, Jian Wu, Caesar Tawfeeq, Alexandr P Kornev, Gianluigi Veglia

Proc Natl Acad Sci U S A· June 2025

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A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring.
Charlotte Bellamy, Hannah Tovell, Selina Schwaighofer, Timothy R Baffi, Janan Arslan, Alexandr Kornev

bioRxiv· May 2025

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Role of the αC-β4 loop in protein kinase structure and dynamics.
Jian Wu, Nisha A Jonniya, Sophia P Hirakis, Cristina Olivieri, Gianluigi Veglia, Alexandr P Kornev

Elife· December 2024

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Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study.
Alexandr P Kornev, Jui-Hung Weng, Rodrigo A Maillard, Susan S Taylor

J Mol Biol· January 2024

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Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.
Jian Wu, Nisha A Jonniya, Sophia P Hirakis, Cristina Olivieri, Gianluigi Veglia, Alexandr P Kornev

bioRxiv· October 2023

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Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.
Alexander C Jones, Alexandr P Kornev, Jui-Hung Weng, Gerard Manning, Susan S Taylor

Biochem J· August 2023

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Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.
Alexander C Jones, Alexandr P Kornev, Jui-Hung Weng, Gerard Manning, Susan S Taylor

bioRxiv· March 2023

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The "violin model": Looking at community networks for dynamic allostery.
Lalima K Madan, Colin L Welsh, Alexandr P Kornev, Susan S Taylor

J Chem Phys· February 2023

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Calculation of centralities in protein kinase A.
Alexandr P Kornev, Phillip C Aoto, Susan S Taylor

Proc Natl Acad Sci U S A· November 2022

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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.
Caila A Pilo, Timothy R Baffi, Alexandr P Kornev, Maya T Kunkel, Mario Malfavon

Sci Signal· September 2022

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From structure to the dynamic regulation of a molecular switch: A journey over 3 decades.
Susan S Taylor, Jian Wu, Jessica G H Bruystens, Jason C Del Rio, Tsan-Wen Lu, Alexandr P Kornev

J Biol Chem· August 2021

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mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Timothy R Baffi, Gema Lordén, Jacob M Wozniak, Andreas Feichtner, Wayland Yeung, Alexandr P Kornev

Sci Signal· April 2021

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Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes.
Alexander C Jones, Susan S Taylor, Alexandra C Newton, Alexandr P Kornev

IUBMB Life· December 2020

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Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.
Pedro M Rodríguez Cruz, Judith Cossins, Jonathan Cheung, Susan Maxwell, Sandeep Jayawant, Alexandr P Kornev

Hum Mutat· March 2020

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Dynamic allostery-based molecular workings of kinase:peptide complexes.
Lalima G Ahuja, Phillip C Aoto, Alexandr P Kornev, Gianluigi Veglia, Susan S Taylor

Proc Natl Acad Sci U S A· July 2019

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The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.
Sven H Schmidt, Matthias J Knape, Daniela Boassa, Natascha Mumdey, Alexandr P Kornev

Proc Natl Acad Sci U S A· July 2019

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Evolution of a dynamic molecular switch.
Susan S Taylor, Hiruy S Meharena, Alexandr P Kornev

IUBMB Life· June 2019

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Tuning the "violin" of protein kinases: The role of dynamics-based allostery.
Lalima G Ahuja, Susan S Taylor, Alexandr P Kornev

IUBMB Life· June 2019

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Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gergő Gógl, Alexandr P Kornev, Attila Reményi, Susan S Taylor

Trends Biochem Sci· April 2019

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Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889.
Yilin Meng, Lalima G Ahuja, Alexandr P Kornev, Susan S Taylor, Benoît Roux

J Mol Biol· October 2018

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Self-organization, entropy and allostery.
Alexandr P Kornev

Biochem Soc Trans· June 2018

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A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.
Yilin Meng, Lalima G Ahuja, Alexandr P Kornev, Susan S Taylor, Benoît Roux

J Mol Biol· March 2018

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Divalent metal ions control activity and inhibition of protein kinases.
Matthias J Knape, Mike Ballez, Nicole C Burghardt, Bastian Zimmermann, Daniela Bertinetti, Alexandr P Kornev

Metallomics· November 2017

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A dynamic hydrophobic core orchestrates allostery in protein kinases.
Jonggul Kim, Lalima G Ahuja, Fa-An Chao, Youlin Xia, Christopher L McClendon, Alexandr P Kornev

Sci Adv· April 2017

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