Publications by authors named "Alexandra Chadt"

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Interplay Between Thrombospondin-1 and CD36 Modulates Platelet-RBC Interaction in Thrombosis and Abdominal Aneurysm Formation.
Kim Jürgen Krott, Tobias Feige, Agnes Bosbach, Alicia Noeme Beele, Irena Krüger, Alexandra Chadt

Circ Res· December 2025

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Impaired mitochondrial ketone body oxidation in insulin resistant states.
Elric Zweck, Sarah Piel, Johannes W Schmidt, Daniel Scheiber, Martin Schön, Alexandra Chadt

EBioMedicine· December 2025

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Magnesium and thiamine supplementation increases renal mitochondrial respiration in lean C57BL/6J but not in obese ob/ob mice.
Sebastian Sill, Fariba Zivehe, Carina Heitmann, Delia Bahn, Julia Busch, Alexandra Chadt

Diabetes Obes Metab· September 2025

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Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI.
Omar Baritello, Simon H Sündermann, Kristian Espinosa-Garnica, Jörg Kempfert, Markus Jähnert, Alexandra Chadt

J Cachexia Sarcopenia Muscle· June 2025

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High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion.
Pia Marlene Förster, Julian Hogenkamp, Moira Fee Pottgießer, Christian Binsch, Awovi Didi Humpert, Alexandra Chadt

Front Physiol· March 2025

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Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling.
Michael Turewicz, Christine Skagen, Sonja Hartwig, Stephan Majda, Kristina Thedinga, Alexandra Chadt

Nat Commun· February 2025

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Inhibition of proline-rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.
Ralf Erkens, Dragos Andrei Duse, Amanda Brum, Alexandra Chadt, Stefanie Becher

Br J Pharmacol· November 2024

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A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium.
Angéline Geiser, Susan Currie, Hadi Al-Hasani, Alexandra Chadt, Gail McConnell

J Cell Sci· October 2024

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Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.
Georgia Lenihan-Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Alexandra Chadt

J Cachexia Sarcopenia Muscle· October 2024

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Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance.
Christian Springer, Christian Binsch, Deborah Weide, Laura Toska, Anna L Cremer, Alexandra Chadt

Diabetes· July 2024

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AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle.
Leon Peifer-Weiß, Hadi Al-Hasani, Alexandra Chadt

Int J Mol Sci· February 2024

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Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high-fat diet-fed mouse model.
Kálmán Bódis, Saida Breuer, Assja Crepzia-Pevzner, Oana-Patricia Zaharia, Martin Schön, Alexandra Chadt

Diabetes Obes Metab· January 2024

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Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse.
Inka Rapöhn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt

Front Endocrinol (Lausanne)· May 2023

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E96V Mutation in the Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice.
Delsi Altenhofen, Jenny Minh-An Khuong, Tanja Kuhn, Sandra Lebek, Sarah Görigk, Alexandra Chadt

Int J Mol Sci· January 2023

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Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.
Tanja Kuhn, Katharina Kaiser, Sandra Lebek, Delsi Altenhofen, Birgit Knebel, Alexandra Chadt

Hum Mol Genet· November 2022

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Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.
Anna Rita Minafra, Alexandra Chadt, Puyan Rafii, Hadi Al-Hasani, Kristina Behnke

Front Endocrinol (Lausanne)· November 2022

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Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.
Sarah Görigk, D Margriet Ouwens, Tanja Kuhn, Delsi Altenhofen, Christian Binsch, Alexandra Chadt

Biochim Biophys Acta Mol Cell Biol Lipids· June 2022

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Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle.
Jeppe K Larsen, Magnus R Larsen, Jesper B Birk, Dorte E Steenberg, Janne R Hingst, Alexandra Chadt

Diabetes· May 2022

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Many Ways to Rome: Exercise, Cold Exposure and Diet-Do They All Affect BAT Activation and WAT Browning in the Same Manner?
Anna K Scheel, Lena Espelage, Alexandra Chadt

Int J Mol Sci· April 2022

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Response to Comment on Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796-2809.
Alexandra Chadt, Hadi Al-Hasani

Diabetes· March 2022

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Identification of Novel Genes Involved in Hyperglycemia in Mice.
Wenke Jonas, Oliver Kluth, Anett Helms, Sarah Voß, Markus Jähnert, Alexandra Chadt

Int J Mol Sci· March 2022

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Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1.
Christian de Wendt, Lena Espelage, Samaneh Eickelschulte, Christian Springer, Laura Toska, Alexandra Chadt

Diabetes· December 2021

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AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase.
Samaneh Eickelschulte, Sonja Hartwig, Ben Leiser, Stefan Lehr, Viola Joschko, Alexandra Chadt

J Biol Chem· August 2021

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Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.
Theresia M Schnurr, Emil Jørsboe, Alexandra Chadt, Inger K Dahl-Petersen, Jonas M Kristensen

Diabetologia· August 2021

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Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development.
Sayeed Ur Rehman, Tanja Schallschmidt, Axel Rasche, Birgit Knebel, Torben Stermann, Alexandra Chadt

Mamm Genome· June 2021

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