Publications by authors named "Alexandra Frommlet"

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Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22.
Elisia Villemure, Tom Januario, Mingshuo Zeng, Hanna G Budayeva, Benjamin T Walters, Alexandra Frommlet

Nat Commun· November 2025

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Correction to "Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-like KRAS G12C Inhibitors".
Alexandra Frommlet, Lan K Nguyen, Matt Saabye, Nicholas F Endres, Melinda M Mulvihill

ACS Omega· March 2025

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Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-Like KRAS G12C Inhibitors.
Alexandra Frommlet, Lan K Nguyen, Matt Saabye, Nicholas F Endres, Melinda M Mulvihill

ACS Omega· December 2024

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Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability.
Hao Wu, Jeremy Murray, Noriko Ishisoko, Alexandra Frommlet, Gauri Deshmukh

J Med Chem· June 2024

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IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition.
Bruno Alicke, Eugene Varfolomeev, Shi Hui Kaylee Lee, Alexandra Frommlet, Savita Ubhayakar

Cell Death Dis· September 2022

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Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Christopher W Davies, Angela J Oh, Rana Mroue, Micah Steffek, John M Bruning, Alexandra Frommlet

Nat Biotechnol· May 2022

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Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband F NMR-Based Screening.
Andreas Lingel, Anna Vulpetti, Tony Reinsperger, Andrew Proudfoot, Regis Denay, Alexandra Frommlet

Angew Chem Int Ed Engl· August 2020

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Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Dirksen E Bussiere, Lili Xie, Honnappa Srinivas, Wei Shu, Ashley Burke, Alexandra Frommlet

Nat Chem Biol· March 2020

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Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Wooseok Han, Xiaolei Ma, Carl J Balibar, Christopher M Baxter Rath, Bret Benton, Alexandra Frommlet

J Am Chem Soc· March 2020

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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Dirksen E Bussiere, Lili Xie, Honnappa Srinivas, Wei Shu, Ashley Burke, Alexandra Frommlet

Nat Chem Biol· January 2020

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A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses.
Joshua R Kane, Susan Fong, Jacob Shaul, Alexandra Frommlet, Andreas O Frank

Elife· January 2020

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Unlocking latent kinetic information from label-free binding.
John G Quinn, Micah Steffek, John M Bruning, Alexandra Frommlet, Melinda M Mulvihill

Sci Rep· December 2019

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Selective Methyl Labeling of Proteins: Enabling Structural and Mechanistic Studies As Well As Drug Discovery Applications by Solution-State NMR.
Andrew Proudfoot, Andreas O Frank, Alexandra Frommlet, Andreas Lingel

Methods Enzymol· August 2019

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Fast and Efficient Fragment-Based Lead Generation by Fully Automated Processing and Analysis of Ligand-Observed NMR Binding Data.
Chen Peng, Alexandra Frommlet, Manuel Perez, Carlos Cobas, Anke Blechschmidt

J Med Chem· April 2016

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