Publications by authors named "Alexandra Whale"

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Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling.
Theodoros Kontogiannis, Christopher McElroy, Milena Quaglia, Carole Foy, Alexandra S Whale

Mol Ther Methods Clin Dev· September 2025

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Next-Generation Methods for More Precise Measurement of Cancer Genetic Changes.
Eloise J Busby, Leandro Lo Cascio, Violette Turon, Alexandra S Whale, Jim F Huggett

Clin Chem· July 2025

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Interlaboratory evaluation of high molecular weight DNA extraction methods for long-read sequencing and structural variant analysis.
Alison S Devonshire, Jordi Morata, Claire Jubin, Rui Pedro Abreu Pereira, Laura Hernandez-Hernandez, Alexandra Whale

BMC Genomics· July 2025

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Interlaboratory assessment of candidate reference materials for lentiviral vector copy number and integration site measurements.
Hua-Jun He, Zhiyong He, Steven P Lund, Laure Turner, Yongjun Fan, Alexandra S Whale

Mol Ther Methods Clin Dev· June 2025

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Characterization of AAV vectors: A review of analytical techniques and critical quality attributes.
Theodoros Kontogiannis, Julian Braybrook, Christopher McElroy, Carole Foy, Alexandra S Whale

Mol Ther Methods Clin Dev· September 2024

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A standardised methodology for the extraction and quantification of cell-free DNA in cerebrospinal fluid and application to evaluation of Alzheimer's disease and brain cancers.
Petros Takousis, Alison S Devonshire, Nicholas Redshaw, Louisa von Baumgarten, Alexandra S Whale

N Biotechnol· December 2022

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Digital PCR can augment the interpretation of RT-qPCR Cq values for SARS-CoV-2 diagnostics.
Alexandra S Whale, Eva K von der Heide, Max Kohlenberg, Anja Brinckmann, Silke Baedker

Methods· May 2022

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Applicability of Control Materials To Support Gene Promoter Characterization and Expression in Engineered Cells Using Digital PCR.
Ana Fernandez-Gonzalez, Simon Cowen, Juhyun Kim, Carole A Foy, Jose Jimenez, Alexandra S Whale

Anal Chem· April 2022

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Comparison of SARS-CoV-2 N gene real-time RT-PCR targets and commercially available mastermixes.
Julianne R Brown, Denise M O'Sullivan, Divya Shah, Laura Atkinson, Rui P A Pereira, Alexandra S Whale

J Virol Methods· September 2021

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Pushing the Envelope with Clinical Use of Digital PCR.
Jim F Huggett, Alison S Devonshire, Alexandra S Whale, Simon Cowen, Carole A Foy

Clin Chem· July 2021

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An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities.
Denise M O'Sullivan, Ronan M Doyle, Sasithon Temisak, Nicholas Redshaw, Alexandra S Whale

Sci Rep· May 2021

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Control Materials and Digital PCR Methods for Evaluation of Circulating Cell-Free DNA Extractions from Plasma.
Alexandra S Whale, Ana Fernandez-Gonzalez, Alice Gutteridge, Alison S Devonshire

Methods Mol Biol· February 2019

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Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine.
Alexandra S Whale, Gerwyn M Jones, Jernej Pavšič, Tanja Dreo, Nicholas Redshaw

Clin Chem· September 2018

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Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA.
Davina Gale, Andrew R J Lawson, Karen Howarth, Mikidache Madi, Bradley Durham, Alexandra S Whale

PLoS One· July 2018

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Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR.
Eloise Busby, Alexandra S Whale, R Bridget Ferns, Paul R Grant, Gary Morley

Sci Rep· April 2017

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International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant.
Alexandra S Whale, Alison S Devonshire, George Karlin-Neumann, Jack Regan, Leanne Javier

Anal Chem· February 2017

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RT-qPCR and RT-Digital PCR: A Comparison of Different Platforms for the Evaluation of Residual Disease in Chronic Myeloid Leukemia.
Mary Alikian, Alexandra S Whale, Susanna Akiki, Kim Piechocki, Celia Torrado

Clin Chem· February 2017

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Fundamentals of multiplexing with digital PCR.
Alexandra S Whale, Jim F Huggett, Svilen Tzonev

Biomol Detect Quantif· December 2016

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Digital PCR dynamic range is approaching that of real-time quantitative PCR.
Gerwyn M Jones, Eloise Busby, Jeremy A Garson, Paul R Grant, Eleni Nastouli, Alexandra S Whale

Biomol Detect Quantif· December 2016

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The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs.
Jody Phelan, Denise M O'Sullivan, Diana Machado, Jorge Ramos, Alexandra S Whale

Genome Med· December 2016

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International Comparison of Enumeration-Based Quantification of DNA Copy-Concentration Using Flow Cytometric Counting and Digital Polymerase Chain Reaction.
Hee-Bong Yoo, Sang-Ryoul Park, Lianhua Dong, Jing Wang, Zhiwei Sui, Alexandra S Whale

Anal Chem· December 2016

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An international comparability study on quantification of mRNA gene expression ratios: CCQM-P103.1.
Alison S Devonshire, Rebecca Sanders, Alexandra S Whale, Gavin J Nixon, Simon Cowen

Biomol Detect Quantif· June 2016

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Next-Generation Sequencing-Assisted DNA-Based Digital PCR for a Personalized Approach to the Detection and Quantification of Residual Disease in Chronic Myeloid Leukemia Patients.
Mary Alikian, Peter Ellery, Martin Forbes, Gareth Gerrard, Dalia Kasperaviciute, Alexandra S Whale

J Mol Diagn· March 2016

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Detection of Rare Drug Resistance Mutations by Digital PCR in a Human Influenza A Virus Model System and Clinical Samples.
Alexandra S Whale, Claire A Bushell, Paul R Grant, Simon Cowen, Ion Gutierrez-Aguirre

J Clin Microbiol· February 2016

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International interlaboratory study comparing single organism 16S rRNA gene sequencing data: Beyond consensus sequence comparisons.
Nathan D Olson, Steven P Lund, Justin M Zook, Fabiola Rojas-Cornejo, Brian Beck, Alexandra S Whale

Biomol Detect Quantif· March 2015

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