Publications by authors named "Alexandre Colavin"

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Harnessing genotype and phenotype data for population-scale variant classification using large language models and bayesian inference.
Toby R Manders, Christopher A Tan, Yuya Kobayashi, Alexander Wahl, Carlos Araya, Alexandre Colavin

Hum Genet· June 2025

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Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
Warren van Loggerenberg, Shahin Sowlati-Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Alexandre Colavin

Am J Hum Genet· October 2023

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Applications of artificial intelligence in clinical laboratory genomics.
Swaroop Aradhya, Flavia M Facio, Hillery Metz, Toby Manders, Alexandre Colavin

Am J Med Genet C Semin Med Genet· September 2023

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Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
Warren van Loggerenberg, Shahin Sowlati-Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Alexandre Colavin

bioRxiv· February 2023

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Extracting phylogenetic dimensions of coevolution reveals hidden functional signals.
Alexandre Colavin, Esha Atolia, Anne-Florence Bitbol, Kerwyn Casey Huang

Sci Rep· January 2022

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Spectrum of splicing variants in disease genes and the ability of RNA analysis to reduce uncertainty in clinical interpretation.
Rebecca Truty, Karen Ouyang, Susan Rojahn, Sarah Garcia, Alexandre Colavin

Am J Hum Genet· April 2021

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Conservation of conformational dynamics across prokaryotic actins.
Natalie Ng, Handuo Shi, Alexandre Colavin, Kerwyn Casey Huang

PLoS Comput Biol· April 2019

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RodZ modulates geometric localization of the bacterial actin MreB to regulate cell shape.
Alexandre Colavin, Handuo Shi, Kerwyn Casey Huang

Nat Commun· March 2018

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Deep Phenotypic Mapping of Bacterial Cytoskeletal Mutants Reveals Physiological Robustness to Cell Size.
Handuo Shi, Alexandre Colavin, Marty Bigos, Carolina Tropini, Russell D Monds

Curr Biol· November 2017

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Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.
Anna D Cunningham, Alexandre Colavin, Kerwyn Casey Huang, Daria Mochly-Rosen

Cell Rep· March 2017

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Strain Library Imaging Protocol for high-throughput, automated single-cell microscopy of large bacterial collections arrayed on multiwell plates.
Handuo Shi, Alexandre Colavin, Timothy K Lee, Kerwyn Casey Huang

Nat Protoc· February 2017

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Rapid, precise quantification of bacterial cellular dimensions across a genomic-scale knockout library.
Tristan Ursell, Timothy K Lee, Daisuke Shiomi, Handuo Shi, Carolina Tropini, Alexandre Colavin

BMC Biol· February 2017

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A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.
Jason M Peters, Alexandre Colavin, Handuo Shi, Tomasz L Czarny, Matthew H Larson

Cell· June 2016

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Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division.
Andrew N Gray, Alexander J F Egan, Inge L Van't Veer, Jolanda Verheul, Alexandre Colavin

Elife· May 2015

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Systematic perturbation of cytoskeletal function reveals a linear scaling relationship between cell geometry and fitness.
Russell D Monds, Timothy K Lee, Alexandre Colavin, Tristan Ursell, Selwyn Quan

Cell Rep· November 2014

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Effects of polymerization and nucleotide identity on the conformational dynamics of the bacterial actin homolog MreB.
Alexandre Colavin, Jen Hsin, Kerwyn Casey Huang

Proc Natl Acad Sci U S A· March 2014

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Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization.
Tristan S Ursell, Jeffrey Nguyen, Russell D Monds, Alexandre Colavin, Gabriel Billings

Proc Natl Acad Sci U S A· March 2014

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