Publications by authors named "Alexandre Gingras"

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A CD25-chemokine receptor complex initiates non-canonical IL-2 signaling.
Hosup Lee, Sarah Hyun Ji Kim, Javid Aceil, Amelia Meecham, Alexandre Gingras

J Biol Chem· November 2025

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A CD25-CCR7 complex initiates non-canonical IL-2 signaling.
Sarah Hyun Ji Kim, Hosup Lee, Alexandre Gingras, Klaus Ley, Jamie B Spangler

bioRxiv· February 2025

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Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors.
Karol R Francisco, Jessica Bruystens, Carmine Varricchio, Sara McCurdy, Jian Wu, Alexandre R Gingras

ACS Pharmacol Transl Sci· November 2023

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IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function.
Hao Sun, Ho-Sup Lee, Sarah Hyun-Ji Kim, Mikhael Fernandes de Lima, Alexandre R Gingras

Cell Rep· August 2023

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Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
Ho-Sup Lee, Hao Sun, Frédéric Lagarrigue, Sarah Hyun Ji Kim, Jay W Fox, Alexandre R Gingras

J Exp Med· August 2022

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Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4 T Cells.
Frederic Lagarrigue, Boyang Tan, Qinyi Du, Zhichao Fan, Miguel A Lopez-Ramirez, Alexandre R Gingras

J Immunol· March 2022

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Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.
Zhongji Liao, Alexandre R Gingras, Frederic Lagarrigue, Mark H Ginsberg, Sanford J Shattil

J Biol Chem· August 2021

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Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.
Miguel Alejandro Lopez-Ramirez, Sara McCurdy, Wenqing Li, Mark K Haynes, Preston Hale, Alexandre R Gingras

FASEB Bioadv· May 2021

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Src-mediated phosphorylation of RIAM promotes integrin activation.
Frédéric Lagarrigue, Alexandre R Gingras

Structure· April 2021

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Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling.
Lai Wen, Alex Marki, Payel Roy, Sara McArdle, Hao Sun, Alexandre R Gingras

Blood· January 2021

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Talin-1 is the principal platelet Rap1 effector of integrin activation.
Frederic Lagarrigue, David S Paul, Alexandre R Gingras, Andrew J Valadez, Hao Sun

Blood· September 2020

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Signal Transduction: Physical Deformation of the Membrane Activates Integrins.
Alexandre R Gingras, Mark H Ginsberg

Curr Biol· May 2020

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Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling.
Hao Sun, Zhichao Fan, Alexandre R Gingras, Miguel A Lopez-Ramirez, Mark H Ginsberg

J Leukoc Biol· February 2020

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Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.
Alexandre R Gingras, Frederic Lagarrigue, Monica N Cuevas, Andrew J Valadez, Marcus Zorovich

J Cell Biol· June 2019

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Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.
Frederic Lagarrigue, Alexandre R Gingras, David S Paul, Andrew J Valadez, Monica N Cuevas

Blood Adv· September 2018

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Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
Hao Sun, Frederic Lagarrigue, Alexandre R Gingras, Zhichao Fan, Klaus Ley

J Cell Biol· April 2018

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Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
Alexandre R Gingras, Wilma Puzon-McLaughlin, Andrey A Bobkov, Mark H Ginsberg

Structure· December 2016

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Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity.
Bart-Jan de Kreuk, Alexandre R Gingras, James Dr Knight, Jian J Liu, Anne-Claude Gingras

Elife· January 2016

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The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex.
Jamie E Marshall, Bayan H A Faraj, Alexandre R Gingras, Rana Lonnen, Md Arif Sheikh

Sci Rep· September 2015

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The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin.
Merry Gunawan, Nandini Venkatesan, Jia Tong Loh, Jong Fu Wong, Heidi Berger, Alexandre R Gingras

Nat Immunol· May 2015

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Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.
Umakhanth Venkatraman Girija, Christopher M Furze, Alexandre R Gingras, Takayuki Yoshizaki, Katsuki Ohtani

BMC Biol· April 2015

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Reconstructing integrin activation in vitro.
Alexandre R Gingras, Feng Ye, Mark H Ginsberg

Methods Mol Biol· February 2014

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Integrins protect cardiomyocytes from ischemia/reperfusion injury.
Hideshi Okada, N Chin Lai, Yoshitaka Kawaraguchi, Peter Liao, Jeffrey Copps, Alexandre R Gingras

J Clin Invest· October 2013

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The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail.
Alexandre R Gingras, Wilma Puzon-McLaughlin, Mark H Ginsberg

J Biol Chem· August 2013

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Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Umakhanth Venkatraman Girija, Alexandre R Gingras, Jamie E Marshall, Roshni Panchal, Md Arif Sheikh

Proc Natl Acad Sci U S A· August 2013

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