Publications by authors named "Alexandre J Debacker"

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Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Minwook Shin, Io Long Chan, Yuming Cao, Alisha M Gruntman, Jonathan Lee, Alexandre J Debacker

Nucleic Acids Res· August 2022

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Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.
Alexandre J Debacker, Jon Voutila, Matthew Catley, David Blakey, Nagy Habib

Mol Ther· August 2020

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Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing.
Alexandre J Debacker, Vivek K Sharma, Pranathi Meda Krishnamurthy, Daniel O'Reilly, Rachel Greenhill

Biochemistry· February 2019

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.
Aamir Mir, Julia F Alterman, Matthew R Hassler, Alexandre J Debacker, Edward Hudgens

Nat Commun· July 2018

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Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.
Hannah M Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J Debacker, Michael P Moazami, Vivek K Sharma

Mol Ther Nucleic Acids· September 2017

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Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification.
Hannah M Pendergraff, Alexandre J Debacker, Jonathan K Watts

Nucleic Acid Ther· August 2016

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