Publications by authors named "Alexandre Reuben"

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Editor's Note: Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Pei-Ling Chen, Whijae Roh, Alexandre Reuben, Zachary A Cooper, Christine N Spencer

Cancer Discov· December 2025

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Continuous Androgen Deprivation Therapy with or Without Metastasis-directed Therapy for Oligometastatic Prostate Cancer: The Multicenter Phase 2 Randomized EXTEND Trial.
Alexander D Sherry, Bilal A Siddiqui, Cara Haymaker, Bryan M Fellman, Marina N Medina-Rosales, Alexandre Reuben

Eur Urol· November 2025

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Spontaneous tumor regression and immunotherapy response demonstrate clonal T-cell expansion in Merkel cell carcinoma.
Patrick Hallaert, John W Roman, Mairead Baker, Natasha T Hill, Jennifer L Marte, Alexandre Reuben

NPJ Precis Oncol· July 2025

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Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception.
Bo Zhu, Pingjun Chen, Muhammad Aminu, Jian-Rong Li, Junya Fujimoto, Alexandre Reuben

Cancer Cell· June 2025

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Intratumoral neutrophil-to-lymphocyte ratio is mirrored by circulating neutrophil-to-lymphocyte ratio in non-small cell lung cancer.
Kyle G Mitchell, Younghee Lee, Nathaniel Deboever, Marcelo V Negrao, Hai T Tran, Alexandre Reuben

J Immunother Cancer· June 2025

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Clinical and Fundamental Research Progressions on Tumor-Infiltrating Lymphocytes Therapy in Cancer.
Jiandong Hu, Mengli Jin, Weihong Feng, Barbara Nassif-Rausseo, Alexandre Reuben

Vaccines (Basel)· May 2025

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Adding Metastasis-Directed Therapy to Standard-of-Care Systemic Therapy for Oligometastatic Breast Cancer (EXTEND): A Multicenter, Randomized Phase 2 Trial.
Jay P Reddy, Alexander D Sherry, Bryan Fellman, Suyu Liu, Tharakeswara Bathala, Alexandre Reuben

Int J Radiat Oncol Biol Phys· March 2025

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Rapid laser ablation-based fabrication of high-density polymer microwell arrays for high-throughput cellular studies.
Desh Deepak Dixit, Kavya L Singampalli, Amit S Niyogi, Amanda Montoya, Alexandre Reuben

Lab Chip· March 2025

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A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma.
Patrick Y Wen, Andrea Manzanera, Caroline Duault, Edgar Gonzalez-Kozlova, Lenika Lopez, Alexandre Reuben

Neuro Oncol· March 2025

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Phase I/II Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas.
Faye M Johnson, Madison P O'Hara, Lacin Yapindi, Peixin Jiang, Hai T Tran, Alexandre Reuben

Clin Cancer Res· February 2025

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Author Correction: Assessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy.
Jiefei Han, Yiting Dong, Xiuli Zhu, Alexandre Reuben, Jianjun Zhang

Nat Commun· February 2025

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TCR-pMHC Binding Specificity Prediction From Structure Using Graph Neural Networks.
Jared K Slone, Anja Conev, Mauricio M Rigo, Alexandre Reuben, Lydia E Kavraki

IEEE Trans Comput Biol Bioinform· January 2025

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Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer.
Ying Jin, Yuefeng Wu, Alexandre Reuben, Liang Zhu, Carl M Gay

Cell Discov· December 2024

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High peripheral T cell diversity is associated with lower risk of toxicity and superior response to dual immune checkpoint inhibitor therapy in patients with metastatic NSCLC.
Mehmet Altan, Ruoxing Li, Ziyi Li, Runzhe Chen, Ajay Sheshadri, Alexandre Reuben

J Immunother Cancer· December 2024

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Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial.
Ethan B Ludmir, Alexander D Sherry, Bryan M Fellman, Suyu Liu, Tharakeswara Bathala, Alexandre Reuben

J Clin Oncol· November 2024

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Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer.
Ying Jin, Yuefeng Wu, Alexandre Reuben, Liang Zhu, Carl M Gay

Cell Discov· September 2024

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Maintenance Pembrolizumab Therapy in Patients with Metastatic HER2-negative Breast Cancer with Prior Response to Chemotherapy.
Toshiaki Iwase, Evan N Cohen, Hui Gao, Angela Alexander, Megumi Kai, Alexandre Reuben, James M Reuben

Clin Cancer Res· June 2024

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The combination of tumor mutational burden and T-cell receptor repertoire predicts the response to immunotherapy in patients with advanced non-small cell lung cancer.
Yalun Li, Liyan Ji, Yingqian Zhang, Jiexin Zhang, Alexandre Reuben

MedComm (2020)· June 2024

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes.
Sahil Seth, Runzhe Chen, Yang Liu, Junya Fujimoto, Lingzhi Hong, Alexandre Reuben

Cancer Innov· June 2024

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TimiGP-Response: the pan-cancer immune landscape associated with response to immunotherapy.
Chenyang Li, Wei Hong, Alexandre Reuben, Linghua Wang, Anirban Maitra

bioRxiv· June 2024

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Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention.
Ana M Bolivar, Fahriye Duzagac, Nan Deng, Laura Reyes-Uribe, Kyle Chang, Alexandre Reuben

Gastroenterology· May 2024

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The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion.
Xin Hu, Bo Zhu, Natalie Vokes, Junya Fujimoto, Frank R Rojas Alvarez, Alexandre Reuben

Res Sq· May 2024

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Assessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy.
Jiefei Han, Yiting Dong, Xiuli Zhu, Alexandre Reuben, Jianjun Zhang

Nat Commun· February 2024

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pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding.
Yi Han, Yuqiu Yang, Yanhua Tian, Farjana J Fattah, Mitchell S von Itzstein, Alexandre Reuben

bioRxiv· December 2023

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Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues.
Qikang Hu, Meredith L Frank, Yang Gao, Liyan Ji, Muyun Peng, Alexandre Reuben

Oncoimmunology· October 2023

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