Publications by authors named "Alexei Y Savinov"

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Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.
Lucas H Armitage, Scott E Stimpson, Katherine E Santostefano, Lina Sui, Similoluwa Ogundare, Alexei Y Savinov

Front Endocrinol (Lausanne)· February 2022

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Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor.
Ilian A Radichev, Jeongheon Yoon, David W Scott, Kurt Griffin, Alexei Y Savinov

Cell Immunol· December 2020

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Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.
Christina Amatya, Ilian A Radichev, Jacob Ellefson, Mark Williams, Alexei Y Savinov

Mol Ther· January 2018

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Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.
Filippo Romanelli, AnthonyMarco Corbo, Maryam Salehi, Manisha C Yadav, Soha Salman, Alexei Y Savinov, Olga V Savinova

PLoS One· October 2017

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Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.
Ilian A Radichev, Lilia V Maneva-Radicheva, Christina Amatya, Maryam Salehi, Camille Parker, Alexei Y Savinov

J Immunol· February 2016

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Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.
Alexei Y Savinov, Maryam Salehi, Manisha C Yadav, Ilian Radichev, José Luis Millán, Olga V Savinova

J Am Heart Assoc· December 2015

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Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
Lilia Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Ilian Radichev, Alexei Y Savinov

PLoS One· June 2015

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Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.
Tadeusz Kolodka, Matthew L Charles, Arvind Raghavan, Ilian A Radichev, Christina Amatya, Alexei Y Savinov

PLoS One· April 2015

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Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.
Ilian A Radichev, Lilia V Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Alexei Y Savinov

Diabetes· October 2014

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Targeting the T-cell membrane type-1 matrix metalloproteinase-CD44 axis in a transferred type 1 diabetes model in NOD mice.
Alexei Y Savinov, Alex Y Strongin

Exp Ther Med· February 2013

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Interference with islet-specific homing of autoreactive T cells: an emerging therapeutic strategy for type 1 diabetes.
Alexei Y Savinov, Paul Burn

Drug Discov Today· July 2010

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Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
Sergey A Shiryaev, Albert G Remacle, Alexei Y Savinov, Andrei V Chernov, Piotr Cieplak

J Biol Chem· October 2009

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Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.
Alexei Y Savinov, Alex Y Strongin

Vitam Horm· June 2009

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Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
Dmitri V Rozanov, Alexei Y Savinov, Vladislav S Golubkov, Olga L Rozanova, Tatiana I Postnova

Mol Cancer Ther· June 2009

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Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.
Sergey A Shiryaev, Alexei Y Savinov, Piotr Cieplak, Boris I Ratnikov, Khatereh Motamedchaboki

PLoS One· April 2009

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Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.
Seung-Hee Lee, Ergeng Hao, Alexei Y Savinov, Ifat Geron, Alex Y Strongin

Transplantation· April 2009

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Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Dmitri V Rozanov, Alexei Y Savinov, Roy Williams, Kang Liu, Vladislav S Golubkov

Cancer Res· June 2008

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Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice.
Alexei Y Savinov, Dmitri V Rozanov, Alex Y Strongin

J Biol Chem· November 2007

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Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Sergey A Shiryaev, Albert G Remacle, Boris I Ratnikov, Nicholas A Nelson, Alexei Y Savinov

J Biol Chem· July 2007

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Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.
Alexei Y Savinov, Alex Y Strongin

IUBMB Life· January 2007

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Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
Alexei Y Savinov, Dmitri V Rozanov, Alex Y Strongin

FASEB J· September 2006

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O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).
Albert G Remacle, Alexei V Chekanov, Vladislav S Golubkov, Alexei Y Savinov, Dmitri V Rozanov

J Biol Chem· June 2006

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Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Dmitri V Rozanov, Alexei Y Savinov, Vladislav S Golubkov, Stephen Tomlinson, Alex Y Strongin

Cancer Res· June 2006

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Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.
Alexei Y Savinov, Albert G Remacle, Vladislav S Golubkov, Maryla Krajewska, Susan Kennedy

Cancer Res· March 2006

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Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.
Alexei V Chekanov, Albert G Remacle, Vladislav S Golubkov, Vladimir S Akatov, Sergey Sikora, Alexei Y Savinov

Arch Biochem Biophys· February 2006

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