Publications by authors named "Alexis Digman"

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Tamoxifen induces partial neuroprotection against manganese toxicity in the dopaminergic REST-deleted male mice.
Alexis Digman, Edward Pajarillo, Sanghoon Kim, Itunu Ajayi, Deok-Soo Son

Neurotoxicology· December 2025

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Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER- mechanism.
Alexis Digman, Edward Pajarillo, Sanghoon Kim, Itunu Ajayi, Deok-Soo Son

Front Mol Neurosci· October 2025

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Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice.
Edward Pajarillo, Alexis Digman, Itunu Ajayi, Sanghoon Kim, Deok-Soo Son

Front Pharmacol· October 2025

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CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes.
Sanghoon Kim, Edward Pajarillo, Alexis Digman, Itunu Ajayi, Deok-Soo Son

Neurochem Res· July 2025

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Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-α/Wnt/β-catenin pathway in neuronal cells.
Alexis Digman, Edward Pajarillo, Sanghoon Kim, Itunu Ajayi, Deok-Soo Son

J Biol Chem· June 2025

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Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice.
Sanghoon Kim, Edward Pajarillo, Alexis Digman, Itunu Ajayi, Deok-Soo Son

Neurotoxicology· May 2025

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Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice.
Edward Pajarillo, Sanghoon Kim, Alexis Digman, Itunu Ajayi, Ivan Nyarko-Danquah

J Biol Chem· September 2024

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Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17β-estradiol afforded protection against this manganese toxicity.
Ivan Nyarko-Danquah, Edward Pajarillo, Sanghoon Kim, Alexis Digman, Harpreet Kaur Multani

Neurotoxicology· July 2024

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The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
Edward Pajarillo, Sanghoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son

J Biol Chem· July 2023

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The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son

bioRxiv· April 2023

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Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation.
Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Cynthia Vied, Deok-Soo Son

Glia· February 2023

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Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies.
Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Harpreet Kaur Multani, Sanghoon Kim

Front Pharmacol· December 2022

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Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice.
Edward Pajarillo, Mark Demayo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son

Glia· October 2022

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Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity.
Edward Pajarillo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Karam F A Soliman

J Biol Chem· December 2021

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Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro.
Asha Rizor, Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Leyah Mooneyham

Neurotoxicology· September 2021

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Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.
Ivan Nyarko-Danquah, Edward Pajarillo, Alexis Digman, Karam F A Soliman, Michael Aschner

Molecules· December 2020

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