Publications by authors named "Alfred Cheng"

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Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential.
Clooney C Y Cheng, Ming Fung Cheung, Ah Young Lee, Qiong Wu, Savio Ho-Chit Chow, Alfred S Cheng

Commun Biol· December 2025

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METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Alfred Sze-Lok Cheng

Adv Sci (Weinh)· December 2025

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Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma.
Martina Mang Leng Lei, Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Xue Qian Wu, Katherine Po Sin Chung, Alfred Sze Lok Cheng

Nat Commun· November 2025

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Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator.
Xiaoyu Liu, Weiqin Yang, Alfred Sze-Lok Cheng

Signal Transduct Target Ther· October 2025

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FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors.
Jiahuan Lu, Thomas Ting-Hei Chan, Yun Wang, Jingya Wang, Zhewen Xiong, Alfred Sze-Lok Cheng

Cancer Res· September 2025

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Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations.
Ziheng Huang, Lin Zhang, Huarong Chen, Xiaodong Liu, Likai Tan, Alfred Sze Lok Cheng

Cancer Res· August 2025

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Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma.
Zhilong Lin, Xiaofei Liu, Houwei Wang, Shumin Li, Ziqiang Miao, Alfred Sze-Lok Cheng

Nat Commun· July 2025

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Developing foundations for biomedical knowledgebases from literature using large language models - A systematic assessment.
Chen Miao, Zhenghao Zhang, Jiamin Chen, Daniel Rebibo, Haoran Wu, Alfred Sze-Lok Cheng

Comput Struct Biotechnol J· July 2025

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BRD9 functions as an HIV-1 latency regulatory factor.
Tsz-Yat Luk, Lok-Yan Yim, Runhong Zhou, Yufei Mo, Huarong Huang, Alfred Sze-Lok Cheng

Proc Natl Acad Sci U S A· May 2025

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Targeting tumour endothelial cells in liver cancer: The end of beginning.
Xiaohang Long, Tsz Tung Kwong, Alfred Sze-Lok Cheng, Stephen Lam Chan

J Hepatol· April 2025

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Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma.
Yalin Tu, Haoran Wu, Chengpeng Zhong, Yan Liu, Zhewen Xiong, Alfred Sze-Lok Cheng

Gut· March 2025

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Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non-Small Cell Lung Cancer With High Programmed Death-Ligand 1 Expression.
Alvin H K Cheung, Zeta Mui, Walter W Yeung, Chit Chow, Mandy F Yu, Alfred S-L Cheng

JTO Clin Res Rep· January 2025

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Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules.
Bowen Ma, Khadija Shahed Khan, Tongyang Xu, Josefina Xeque Amada, Zhihao Guo, Alfred Sze-Lok Cheng

J Am Chem Soc· April 2024

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Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma.
Liuyang Cai, Hengyan Zhu, Qianqian Mou, Po Yee Wong, Linlin Lan, Alfred S L Cheng

NPJ Biofilms Microbiomes· April 2024

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The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.
Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alfred S L Cheng

Clin Transl Med· December 2023

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Accurate identification of structural variations from cancer samples.
Le Li, Chenyang Hong, Jie Xu, Claire Yik-Lok Chung, Alden King-Yung Leung, Lixin Cheng, Alfred Sze-Lok Cheng

Brief Bioinform· November 2023

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Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma.
Zhewen Xiong, Stephen Lam Chan, Jingying Zhou, Joaquim S L Vong, Tsz Tung Kwong, Alfred Sze-Lok Cheng

Gut· September 2023

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Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients.
Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, Alfred Sze-Lok Cheng

Gut· August 2023

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The E2F1-HOXB9/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer.
Jinglin Zhang, Bonan Chen, Yifei Wang, Xiaoli Liu, Huan Yan, Alfred Sl Cheng

J Pathol· August 2023

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Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing.
Qing Liu, Qiaoyun Long, Jiayu Zhao, Wenjie Wu, Zexin Lin, Alfred S Cheng

Research (Wash D C)· June 2023

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Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models.
Stanley K K Cheung, Jacinda Kwok, Penelope M Y Or, Chi Wai Wong, Bo Feng, Alfred S L Cheng

Sci Rep· April 2023

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Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways.
Jinglin Zhang, Bonan Chen, Hui Li, Yifei Wang, Xiaoli Liu, Alfred Sl Cheng

J Pathol· February 2023

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Compromised browning in white adipose tissue of ageing people.
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Alfred S Cheng

Eur J Endocrinol· February 2023

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Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.
Ping Sun, Jing Wang, Khadija S Khan, Weiqin Yang, Billy Wai-Lung Ng, Alfred Sze-Lok Cheng

J Med Chem· December 2022

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Meltdown of the cold tumour microenvironment: a new 'translational' approach to augment immunotherapy efficacy.
Alfred Sze-Lok Cheng

Gut· December 2022

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