Publications by authors named "Alfred P Spada"

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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo.
Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Alfred P Spada

Clin Gastroenterol Hepatol· March 2019

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Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension.
Guadalupe Garcia-Tsao, Michael Fuchs, Mitchell Shiffman, Brian B Borg, Nikolaos Pyrsopoulos, Alfred P Spada

Hepatology· February 2019

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Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo.
Anna K Kopec, Alfred P Spada, Patricia C Contreras, Nigel Mackman, James P Luyendyk

Toxicol Sci· April 2018

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First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Steven D Linton, Teresa Aja, Robert A Armstrong, Xu Bai, Long-Shiuh Chen, Alfred P Spada

J Med Chem· November 2005

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A nucleotide binding site in caspase-9 regulates apoptosome activation.
David Chereau, Hua Zou, Alfred P Spada, Joe C Wu

Biochemistry· April 2005

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Conformational restrictions in the active site of unliganded human caspase-3.
Chao-Zhou Ni, Chenglong Li, Joe C Wu, Alfred P Spada, Kathryn R Ely

J Mol Recognit· February 2004

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Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.
Michael R Myers, Wei He, Barbara Hanney, Natalie Setzer, Martin P Maguire, Alfred P Spada

Bioorg Med Chem Lett· September 2003

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Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor.
Wei He, Michael R Myers, Barbara Hanney, Alfred P Spada, Glenda Bilder

Bioorg Med Chem Lett· September 2003

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Structural and functional analysis of caspase active sites.
David Chéreau, Lalitha Kodandapani, Kevin J Tomaselli, Alfred P Spada, Joe C Wu

Biochemistry· April 2003

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Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
Sébastien Maignan, Jean-Pierre Guilloteau, Yong Mi Choi-Sledeski, Michael R Becker, William R Ewing, Alfred P Spada

J Med Chem· February 2003

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Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency.
Mark Czekaj, Scott I Klein, Kevin R Guertin, Charles J Gardner, Allison L Zulli, Alfred P Spada

Bioorg Med Chem Lett· June 2002

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Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.
Kevin R Guertin, Charles J Gardner, Scott I Klein, Allison L Zulli, Mark Czekaj, Alfred P Spada

Bioorg Med Chem Lett· June 2002

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Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.
Wei He, Barbara Hanney, Michael R Myers, Stephen Condon, Michael R Becker, Alfred P Spada

Bioorg Med Chem Lett· March 2002

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