Publications by authors named "Alfred Singer"

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New insights into developmental fate decisions by autoreactive CD4 thymocytes.
Xuguang Tai, Alfred Singer

Clin Transl Med· February 2024

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CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus.
Mohamed Elsherif Badr, Zhongmei Zhang, Xuguang Tai, Alfred Singer

Science· November 2023

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How autoreactive thymocytes differentiate into regulatory versus effector CD4 T cells after avoiding clonal deletion.
Xuguang Tai, Alyssa Indart, Mirelle Rojano, Jie Guo, Nicolai Apenes, Alfred Singer

Nat Immunol· April 2023

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MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction.
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D Sun, Alfred Singer

Front Immunol· August 2022

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Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.
Miho Shinzawa, E Ashley Moseman, Selamawit Gossa, Yasuko Mano, Abhisek Bhattacharya, Alfred Singer

Nat Immunol· May 2022

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Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Alfred Singer

Front Immunol· April 2021

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Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.
Jinghua Lu, François Van Laethem, Ingrid Saba, Jonathan Chu, Anastasia N Tikhonova, Alfred Singer

J Immunol· June 2020

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E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
Tejas Kadakia, Xuguang Tai, Michael Kruhlak, Jan Wisniewski, Il-Young Hwang, Alfred Singer

J Exp Med· August 2019

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Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Alfred Singer

Nat Commun· March 2019

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A TCR mechanotransduction signaling loop induces negative selection in the thymus.
Jinsung Hong, Chenghao Ge, Prithiviraj Jothikumar, Zhou Yuan, Baoyu Liu, Alfred Singer

Nat Immunol· December 2018

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CD69 prevents PLZF innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation.
Motoko Y Kimura, Akemi Igi, Koji Hayashizaki, Yukiyoshi Mita, Miho Shinzawa, Alfred Singer

Nat Commun· September 2018

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Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation.
Anne Gegonne, Qing-Rong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Dinah S Singer

Cell Rep· July 2018

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Identification of lineage-specifying cytokines that signal all CD8-cytotoxic-lineage-fate 'decisions' in the thymus.
Ruth Etzensperger, Tejas Kadakia, Xuguang Tai, Amala Alag, Terry I Guinter, Alfred Singer

Nat Immunol· November 2017

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T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.
Asaf Madi, Asaf Poran, Eric Shifrut, Shlomit Reich-Zeliger, Erez Greenstein, Alfred Singer

Elife· July 2017

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Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.
Motoko Y Kimura, Julien Thomas, Xuguang Tai, Terry I Guinter, Miho Shinzawa, Alfred Singer

Nat Immunol· December 2016

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Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71.
Enrico Brugnera, Avinash Bhandoola, Ricardo Cibotti, Qing Yu, Terry I Guinter, Alfred Singer

J Immunol· March 2016

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TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.
Kensuke Takada, Francois Van Laethem, Yan Xing, Kazuyuki Akane, Haruhiko Suzuki, Alfred Singer

Nat Immunol· October 2015

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Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
Leonid A Pobezinsky, Ruth Etzensperger, Susanna Jeurling, Amala Alag, Tejas Kadakia, Alfred Singer

Nat Immunol· May 2015

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Basis of Treg development in the thymus.
Xuguang Tai, Alfred Singer

Cell Cycle· April 2015

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T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.
Gil Katz, Leonid A Pobezinsky, Susanna Jeurling, Miho Shinzawa, Francois Van Laethem, Alfred Singer

Sci Signal· August 2014

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The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
Megan A Luckey, Motoko Y Kimura, Adam T Waickman, Lionel Feigenbaum, Alfred Singer

Nat Immunol· July 2014

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[Crucial role of CD4 and CD8 coreceptors in antigen recognition of αβT lymphocytes].
François Van Laethem, Ingrid Saba, Anastasia N Tikhonova, Alfred Singer

Med Sci (Paris)· May 2014

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Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.
Jie Mu, Xuguang Tai, Shankar S Iyer, Jocelyn D Weissman, Alfred Singer, Dinah S Singer

J Immunol· March 2014

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Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
François Van Laethem, Anastasia N Tikhonova, Leonid A Pobezinsky, Xuguang Tai, Motoko Y Kimura, Alfred Singer

Cell· September 2013

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Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Xuguang Tai, Batu Erman, Amala Alag, Jie Mu, Motoko Kimura, Dinah S Singer, Alfred Singer

Immunity· June 2013

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