Publications by authors named "Alfreda Beasley"

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Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil.
Emmanuel P Bessay, Mitsi A Blount, Roya Zoraghi, Alfreda Beasley, Kennard A Grimes

J Pharmacol Exp Ther· April 2008

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Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.
Mitsi A Blount, Roya Zoraghi, Emmanuel P Bessay, Alfreda Beasley, Sharron H Francis

J Pharmacol Exp Ther· November 2007

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Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.
Emmanuel P Bessay, Roya Zoraghi, Mitsi A Blount, Kennard A Grimes, Alfreda Beasley

Front Biosci· January 2007

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Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.
James L Weeks, Mitsi A Blount, Alfreda Beasley, Roya Zoraghi, Melissa K Thomas

Methods Mol Biol· September 2005

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High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.
Jackie D Corbin, Alfreda Beasley, Mitsi A Blount, Sharron H Francis

Biochem Biophys Res Commun· September 2005

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Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).
Jackie D Corbin, Alfreda Beasley, Mitsi A Blount, Sharron H Francis

Neurochem Int· November 2004

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Sildenafil citrate does not affect cardiac contractility in human or dog heart.
Jackie Corbin, Stephen Rannels, Doss Neal, Paul Chang, Kennard Grimes, Alfreda Beasley

Curr Med Res Opin· August 2004

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Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
Mitsi A Blount, Alfreda Beasley, Roya Zoraghi, Konjeti R Sekhar, Emmanuel P Bessay

Mol Pharmacol· July 2004

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[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.
Jackie D Corbin, Mitsi A Blount, James L Weeks, Alfreda Beasley, Karl P Kuhn

Mol Pharmacol· June 2003

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