Publications by authors named "Alison Crook"

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Safety and broad immunogenicity of HIVconsvX conserved mosaic candidate T-cell vaccines vectored by ChAdOx1 and MVA in HIV-CORE 006: a double-blind, randomised, placebo-controlled phase 1 trial in healthy adults living without HIV-1 in eastern and southern Africa.
Chama Chanda, Freddie Kibengo, Michael Mutua, Fred Ogada, Vincent Muturi-Kioi, Alison Crook

Lancet Microbe· June 2025

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Safety and immunogenicity of the ChAdOx1-MVA-vectored conserved mosaic HIVconsvX candidate T-cell vaccines in HIV-CORE 005.2, an open-label, dose-escalation, first-in-human, phase 1 trial in adults living without HIV-1 in the UK.
Nicola Borthwick, Natalia Fernandez, Peter J Hayes, Edmund G-T Wee, Belkis M Akis Yildirim, Alison Crook

Lancet Microbe· March 2025

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Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-Cell Vaccine.
Edmund G-T Wee, Sarah Kempster, Deborah Ferguson, Joanna Hall, Claire Ham, Alison Crook

Vaccines (Basel)· August 2024

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Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation.
Zara Hannoun, Edmund G Wee, Alison Crook, Stefano Colloca, Stefania Di Marco

Vaccines (Basel)· June 2022

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HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02).
Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C Puertas, Alison Crook

Front Immunol· March 2021

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Specificity of CD8 T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya.
Yehia S Mohamed, Nicola J Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Alison Crook

Vaccines (Basel)· May 2020

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Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80.
Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Alison Crook

EClinicalMedicine· January 2020

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Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study).
Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Alison Crook

EClinicalMedicine· June 2019

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Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.
Md Niaz Rahim, Edmund G Wee, Shihua He, Jonathan Audet, Kevin Tierney, Alison Crook

PLoS Pathog· February 2019

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Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1.
Nicola J Borthwick, Thirusha Lane, Nathifa Moyo, Alison Crook, Jung Min Shim

PLoS One· November 2018

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Long-term follow up of human T-cell responses to conserved HIV-1 regions elicited by DNA/simian adenovirus/MVA vaccine regimens.
Nathifa Moyo, Nicola J Borthwick, Edmund G Wee, Silvia Capucci, Alison Crook

PLoS One· September 2017

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Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects.
Gemma Hancock, Sara Morón-López, Jakub Kopycinski, Maria C Puertas, Eleni Giannoulatou, Alison Crook

J Int AIDS Soc· May 2017

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Broad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults.
Gaudensia Mutua, Bashir Farah, Robert Langat, Jackton Indangasi, Simon Ogola, Alison Crook

Mol Ther Methods Clin Dev· September 2016

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Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.
Emma-Jo Hayton, Annie Rose, Umar Ibrahimsa, Mariarosaria Del Sorbo, Stefania Capone, Alison Crook

PLoS One· March 2015

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