Publications by authors named "Alison Findlay"

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A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis.
Pankit Vachhani, Peter Tan, Anne-Marie Watson, Shang-Ju Wu, Ross Baker, Alison Findlay

Haematologica· October 2025

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A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan-lysyl oxidase inhibitor PXS-6302 in mature scars.
Natalie Morellini, Peijun Gong, Suzanne Rea, Helen Douglas, Phuoc Hao Ho, Alison Findlay

Sci Transl Med· September 2025

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The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.
Lara Perryman, Alison Findlay, Jana Baskar, Brett Charlton, Jonathan Foot

Sci Rep· July 2025

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Stabilization of the open conformation οf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor.
Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D Findlay, Jonathan S Foot

Protein Sci· September 2024

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Jessica L Chitty, Michelle Yam, Lara Perryman, Amelia L Parker, Joanna N Skhinas, Alison D Findlay

Nat Cancer· September 2023

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Author Correction: Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.
Nutan Chaudhari, Alison D Findlay, Andrew W Stevenson, Tristan D Clemons, Yimin Yao

Nat Commun· January 2023

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Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.
Jonathan S Foot, Alberto Buson, Mandar Deodhar, Alison D Findlay, Alan D Robertson

Bioorg Med Chem Lett· October 2022

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Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.
Nutan Chaudhari, Alison D Findlay, Andrew W Stevenson, Tristan D Clemons, Yimin Yao

Nat Commun· September 2022

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Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis.
Yimin Yao, Alison Findlay, Jessica Stolp, Benjamin Rayner, Kjetil Ask

Int J Mol Sci· May 2022

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An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies.
Alison Findlay, Craig Turner, Heidi Schilter, Mandar Deodhar, Wenbin Zhou

Clin Transl Med· November 2021

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Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice.
Orly Leiva, Seng Kah Ng, Shinobu Matsuura, Vipul Chitalia, Hector Lucero, Alison Findlay

Int J Hematol· December 2019

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Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.
Alison D Findlay, Jonathan S Foot, Alberto Buson, Mandar Deodhar, Andrew G Jarnicki

J Med Chem· November 2019

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The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.
Heidi Schilter, Alison D Findlay, Lara Perryman, Tin T Yow, Joshua Moses

J Cell Mol Med· March 2019

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Synthetic Studies on the Natural Product Myrsinoic Acid F Reveal Biologically Active Analogues.
Jiri Mikusek, Jeremy Nugent, Jas S Ward, Brett D Schwartz, Alison D Findlay

Org Lett· July 2018

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Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.
Joan Chang, Morghan C Lucas, Lidia E Leonte, Marc Garcia-Montolio, Lukram Babloo Singh, Alison D Findlay

Oncotarget· April 2017

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A multicentre validation of Metasin: a molecular assay for the intraoperative assessment of sentinel lymph nodes from breast cancer patients.
Priya Sai-Giridhar, Salma Al-Ramadhani, Dilushana George, Preethi Gopinath, William Andrews, Alison Findlay

Histopathology· May 2016

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The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts.
Heidi Schilter, Carmen Z Cantemir-Stone, Vladimir Leksa, Anna Ohradanova-Repic, Alison D Findlay

Immunol Lett· June 2015

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PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.
Jonathan S Foot, Tin T Yow, Heidi Schilter, Alberto Buson, Mandar Deodhar, Alison D Findlay

J Pharmacol Exp Ther· November 2013

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The Au(I)-catalyzed intramolecular hydroarylation of terminal alkynes under mild conditions: application to the synthesis of 2H-chromenes, coumarins, benzofurans, and dihydroquinolines.
Rajeev S Menon, Alison D Findlay, Alex C Bissember, Martin G Banwell

J Org Chem· November 2009

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A chemoenzymatic total synthesis of (+)-amabiline.
Alison D Findlay, Martin G Banwell

Org Lett· July 2009

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Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum.
Ian Paterson, Alison D Findlay, Christian Noti

Chem Asian J· April 2009

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Total synthesis of (-)-spirangien A and its methyl ester.
Ian Paterson, Alison D Findlay, Christian Noti

Chem Commun (Camb)· December 2008

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Synthesis of an advanced C10-C32 spiroacetal fragment and assignment of the absolute configuration of spirangien A.
Ian Paterson, Alison D Findlay, Edward A Anderson

Angew Chem Int Ed Engl· October 2007

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Total synthesis and stereochemical reassignment of (+)-dolastatin 19.
Ian Paterson, Alison D Findlay, Gordon J Florence

Org Lett· May 2006

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Engineering mRNA translation initiation to enhance transient gene expression in chinese hamster ovary cells.
Michèle F Underhill, Clare Coley, John R Birch, Alison Findlay, Robert Kallmeier

Biotechnol Prog· October 2003

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