Publications by authors named "Alison Goate"

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Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder.
Anna S Warden, Nihal A Salem, Eric Brenner, Greg T Sutherland, Julia Stevens, Alison M Goate

Biol Psychiatry· January 2026

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Lymphoid gene expression supports neuroprotective microglia function.
Pinar Ayata, Jessica M Crowley, Matthew F Challman, Vinaya Sahasrabuddhe, Maud Gratuze, Alison M Goate

Nature· December 2025

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Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms.
Yun Freudenberg-Hua, Luca Giliberto, Cristina d'Abramo, Wentian Li, Yilong Ma, Alison Goate

Mol Psychiatry· October 2025

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Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.
Nicholas C Green, Hongyu Gao, Xiaona Chu, Qiuyue Yuan, Patrick McGuire, Alison M Goate

Nat Commun· October 2025

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The curious case of a heterozygous loss-of-function variant associated with early-onset Alzheimer's disease.
Inmaculada Sanjuan-Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert

Mol Neurodegener Adv· October 2025

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A rapid and robust protocol for generating loss-of-function alleles in pluripotent stem cells.
Erdene Baljinnyam, Laura Grisanti, Shalini Tattari, Chiara Pedicone, Bhavana Shewale, Alison M Goate

STAR Protoc· September 2025

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APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition.
Braxton R Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo, Diede W M Broekaart, Leon Wang, Alison M Goate

bioRxiv· September 2025

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The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology.
Eric M McDade, Nicolas R Barthélemy, Guoqiao Wang, Yan Li, Yuchen Cao, Alison M Goate

Alzheimers Dement· September 2025

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Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's and Parkinson's disease using Polygenic Risk Scores and Mendelian Randomization.
Aadrita Chatterjee, Brian Alvarez, Rakshya U Sharma, Caroline Jonson, Heather M Wilkins, Alison Goate

medRxiv· September 2025

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Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.
Jared M Phillips, Logan C Dumitrescu, Derek B Archer, Alexandra N Regelson, Shubhabrata Mukherjee, Alison M Goate

Brain· August 2025

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The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer's Disease.
Inmaculada Sanjuan Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert

Res Sq· August 2025

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Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Alison Goate

Nat Genet· July 2025

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Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Anna Podleśny-Drabiniok, Carmen Romero-Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Alison M Goate

Cell Rep· July 2025

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Alison M Goate

Genome Biol· July 2025

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Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells.
Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Alison M Goate

Mov Disord· May 2025

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Childhood Trauma and are Associated with Adolescent Brain Function, Posttraumatic Stress, and Alcohol-related Outcomes.
Zoe E Neale, Megan E Cooke, Jasmine Cárcamo, Maissa Trabilsy, Peter B Barr, Alison M Goate

medRxiv· May 2025

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GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy.
Carlos Cruchaga, Jigyasha Timsina, Chenyang Jiang, Daniel McCartney, Feifei Tao, Alison Goate

Res Sq· May 2025

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Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project.
Dongyu Wang, Alexandra Scalici, Yanbing Wang, Honghuang Lin, Achilleas Pitsillides, Alison M Goate

J Alzheimers Dis· April 2025

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Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Alison A Goate

Lancet Neurol· April 2025

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Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing.
Jack Humphrey, Erica Brophy, Roman Kosoy, Biao Zeng, Elena Coccia, Alison M Goate

Nat Genet· March 2025

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intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk.
Lien Nguyen, Ramadan Ajredini, Shu Guo, Lisa E L Romano, Rodrigo F Tomas, Alison Goate

Proc Natl Acad Sci U S A· February 2025

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and variants differentially influence glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants.
Yun Freudenberg-Hua, Luca Giliberto, Cristina D'Abramo, Wentian Li, Yilong Ma, Alison Goate

medRxiv· February 2025

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Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial.
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Alison A Goate

medRxiv· January 2025

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Divergent Effects of and Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice.
Joan Cruz-Sese, Marta Mirón-Alcala, Maria Alfonso-Triguero, Jon Olalde, Leire Ruiz, Alison Goate

bioRxiv· January 2025

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