Publications by authors named "Alison N McCracken"

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Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.
Vaishali Jayashankar, Peter Kubiniok, Alison N McCracken, Rebeca G Gentry, Kazumi H Eckenstein

EMBO J· August 2025

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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.
Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken

Nucleic Acids Res· February 2023

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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines.
Sylvestre P J T Bachollet, Vito Vece, Alison N McCracken, Brendan T Finicle, Elizabeth Selwan

ACS Med Chem Lett· May 2020

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Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720.
Jessica A Kemp, Andrew Keebaugh, Julius A Edson, David Chow, Michael T Kleinman, Alison N McCracken

Bioconjug Chem· March 2020

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Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.
Jean-Baptiste Garsi, Vito Vece, Lorenzo Sernissi, Catherine Auger-Morin, Stephen Hanessian, Alison N McCracken

Bioorg Med Chem Lett· September 2019

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Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.
Peter Kubiniok, Brendan T Finicle, Fanny Piffaretti, Alison N McCracken, Michael Perryman

Mol Cell Proteomics· March 2019

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In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.
Jean-Baptiste Garsi, Lorenzo Sernissi, Vito Vece, Stephen Hanessian, Alison N McCracken

Eur J Med Chem· November 2018

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Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.
Brendan T Finicle, Manuel U Ramirez, Gang Liu, Elizabeth M Selwan, Alison N McCracken

J Cell Sci· June 2018

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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Seong M Kim, Saurabh G Roy, Bin Chen, Tiffany M Nguyen, Ryan J McMonigle, Alison N McCracken

J Clin Invest· November 2016

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Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Michael S Perryman, Jérémie Tessier, Timothy Wiher, Heather O'Donoghue, Alison N McCracken

Bioorg Med Chem· September 2016

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Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.
Bin Chen, Saurabh G Roy, Ryan J McMonigle, Andrew Keebaugh, Alison N McCracken

ACS Chem Biol· February 2016

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Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14.
Alison N McCracken, Aimee L Edinger

Biochem J· September 2015

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Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
Rebecca Fransson, Alison N McCracken, Bin Chen, Ryan J McMonigle, Aimee L Edinger

ACS Med Chem Lett· October 2013

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Nutrient transporters: the Achilles' heel of anabolism.
Alison N McCracken, Aimee L Edinger

Trends Endocrinol Metab· April 2013

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