Publications by authors named "Alvaro Ardiles"

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Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy.
Claudia García-Rodríguez, Carolina Flores-Muñoz, Paola Fernández, Marcela Escobar, Álvaro O Ardiles

Biol Res· December 2025

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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring.
Enrique González-Madrid, Ma Andreina Rangel-Ramírez, María C Opazo, Sebastián A Espinoza, Daniela Elgueta, Álvaro O Ardiles

Sci Rep· November 2025

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Pannexin 1 channels: A bridge between synaptic plasticity and learning and memory processes.
Javiera Illanes-González, Carolina Flores-Muñoz, Nathalia Vitureira, Álvaro O Ardiles

Neurosci Biobehav Rev· July 2025

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The synaptic availability of GluA1 is reduced in hippocampal neurons of a murine model of dynamin-2 linked autosomal dominant centronuclear myopathy.
Carolina Flores-Muñoz, Marjorie Labraña-Allende, Michelle Mattar-Araos, Barbara Gomez-Soto, Joaquin Silva-Guzman, Alvaro O Ardiles

Sci Prog· May 2025

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Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers.
Jorge Arriagada, Daymara Mercerón, Álvaro Ardiles, Pablo Muñoz, Andrea Paula-Lima

Biochem Biophys Res Commun· January 2025

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The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes.
Claudia García-Rodríguez, Yorley Duarte, Álvaro O Ardiles, Juan C Sáez

J Neurochem· June 2024

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Ca permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death.
Magdiel Salgado, Valeria Márquez-Miranda, Luciano Ferrada, Maximiliano Rojas, Gonzalo Poblete-Flores, Álvaro O Ardiles

Proc Natl Acad Sci U S A· June 2024

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A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease.
Jorge Arriagada-Diaz, Carolina Flores-Muñoz, Bárbara Gómez-Soto, Marjorie Labraña-Allende, Michelle Mattar-Araos, Alvaro O Ardiles

Neuropathol Appl Neurobiol· August 2023

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The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Claudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, Álvaro O Ardiles, Mei Li Díaz-Hung

Mol Ther· July 2023

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Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity.
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D Martínez, Álvaro O Ardiles

Biomolecules· May 2023

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Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation.
Claudia García-Rodríguez, Paula Mujica, Javiera Illanes-González, Araceli López, Camilo Vargas, Álvaro O Ardiles

Biomedicines· May 2023

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mGluR-dependent plasticity in rodent models of Alzheimer's disease.
Gonzalo Valdivia, Alvaro O Ardiles, Abimbola Idowu, Claudia Salazar, Hey-Kyoung Lee

Front Synaptic Neurosci· March 2023

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Neurobiology of Disorganized Attachment: A Review of Primary Studies on Human Beings.
Marcelo Arancibia, Mariane Lutz, Álvaro Ardiles, Camila Fuentes

Neurosci Insights· February 2023

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Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Felipe Cabral-Miranda, Giovanni Tamburini, Gabriela Martinez, Alvaro O Ardiles, Danilo B Medinas

EMBO J· November 2022

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The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons.
Carolina Flores-Muñoz, Francisca García-Rojas, Miguel A Pérez, Odra Santander, Elena Mery, Álvaro O Ardiles

Cells· November 2022

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The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.
Débora Buendía, Tatiana Guncay, Macarena Oyanedel, Makarena Lemus, Alejandro Weinstein, Álvaro O Ardiles

Brain Sci· September 2022

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Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease.
Jorge Arriagada-Diaz, Lorena Prado-Vega, Ana M Cárdenas, Alvaro O Ardiles, Arlek M Gonzalez-Jamett

Neuroscientist· February 2022

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A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity.
Stefan Mihalas, Alvaro Ardiles, Kaiwen He, Adrian Palacios, Alfredo Kirkwood

Front Synaptic Neurosci· August 2021

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[Aducanumab: Lack of consistency between preclinical and clinical evidence].
Álvaro O Ardiles, Marcelo Arancibia, Mañane Lutz, Julio Riquelme, Juan Pablo Gigoux

Rev Med Chil· June 2021

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Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease.
Pablo Muñoz, Álvaro O Ardiles, Boris Pérez-Espinosa, Cristian Núñez-Espinosa, Andrea Paula-Lima

Mech Ageing Dev· July 2020

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Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation.
Francisca García, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Álvaro O Ardiles

Mar Drugs· June 2020

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Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus.
Lily Y-L Chang, Alvaro O Ardiles, Cheril Tapia-Rojas, Joaquin Araya, Nibaldo C Inestrosa

Front Neurosci· March 2020

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Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease.
Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Paula Mujica, Ivana Gajardo, Álvaro O Ardiles

Front Cell Neurosci· March 2020

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Molecular and Cellular Mechanisms of Synaptopathies.
Alvaro O Ardiles, Andreas M Grabrucker, Francisco G Scholl, Gabby Rudenko, Tiziana Borsello

Neural Plast· April 2018

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Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice.
Ivana Gajardo, Claudia S Salazar, Daniela Lopez-Espíndola, Carolina Estay, Carolina Flores-Muñoz, Álvaro O Ardiles

Front Mol Neurosci· April 2018

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