Publications by authors named "Amanda Sheets"

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Impact of updated regulatory guidelines on study results in contemporary uncomplicated urinary tract infection clinical trials and implications for trial conduct and drug development: a comparative analysis with EAGLE-2 and EAGLE-3.
Florian Wagenlehner, Keith S Kaye, David A Talan, Amanda J Sheets, Nicole E Scangarella-Oman

Contemp Clin Trials Commun· December 2025

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Efficacy and activity of gepotidacin against bacterial uropathogens, including drug-resistant phenotypes, in females with uncomplicated urinary tract infections: results from two global, pivotal, phase 3 trials (EAGLE-2 and EAGLE-3).
Nicole E Scangarella-Oman, Deborah L Butler, John Breton, Derrek Brown, Cara Kasapidis, Amanda J Sheets

Antimicrob Agents Chemother· October 2025

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Efficacy and activity of gepotidacin against bacterial uropathogens, including subsets with molecularly characterized resistance mechanisms and genotypes/epidemiological clones, in females with uncomplicated urinary tract infections: results from two global, pivotal, phase 3 trials (EAGLE-2 and EAGLE-3).
Nicole E Scangarella-Oman, Deborah L Butler, John Breton, Derrek Brown, Cara Kasapidis, Amanda J Sheets

Antimicrob Agents Chemother· October 2025

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Plain language summary: efficacy and safety of gepotidacin, a new oral antibiotic, compared with nitrofurantoin, a commonly used oral antibiotic, for treating uncomplicated urinary tract infection.
Florian Wagenlehner, Caroline R Perry, Thomas M Hooton, Nicole E Scangarella-Oman, Helen Millns, Amanda Sheets

Future Microbiol· March 2025

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Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
Florian Wagenlehner, Caroline R Perry, Thomas M Hooton, Nicole E Scangarella-Oman, Helen Millns, Amanda Sheets

Lancet· February 2024

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Efficacy of delafloxacin versus moxifloxacin against atypical bacterial respiratory pathogens in adults with community-acquired bacterial pneumonia (CABP): Data from the Delafloxacin Phase 3 CABP Trial.
Sandra McCurdy, Ashley Nenninger, Amanda Sheets, Kara Keedy, Laura Lawrence

Int J Infect Dis· August 2020

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Efficacy of Delafloxacin versus Moxifloxacin against Bacterial Respiratory Pathogens in Adults with Community-Acquired Bacterial Pneumonia (CABP): Microbiology Results from the Delafloxacin Phase 3 CABP Trial.
Sandra McCurdy, Kara Keedy, Laura Lawrence, Ashley Nenninger, Amanda Sheets

Antimicrob Agents Chemother· February 2020

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SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia.
Thomas M File, Barbara Rewerska, Violeta Vucinic-Mihailovic, Joven Roque V Gonong, Anita F Das, Amanda Sheets

Clin Infect Dis· October 2016

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Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL).
Carlos M Barrera, Analia Mykietiuk, Hristo Metev, Mimi Floarea Nitu, Najumuddin Karimjee, Amanda Sheets

Lancet Infect Dis· April 2016

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Cooperative roles for fimbria and filamentous hemagglutinin in Bordetella adherence and immune modulation.
Erich V Scheller, Jeffrey A Melvin, Amanda J Sheets, Peggy A Cotter

mBio· May 2015

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The Haemophilus cryptic genospecies Cha adhesin has at least two variants that differ in host cell binding, bacterial aggregation, and biofilm formation properties.
Jessica R McCann, Amanda J Sheets, Susan Grass, Joseph W St Geme

J Bacteriol· May 2014

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Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.
Michael W Henderson, Carol S Inatsuka, Amanda J Sheets, Corinne L Williams, David J Benaron

Infect Immun· June 2012

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Adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem Peptide repeats.
Amanda J Sheets, Joseph W St Geme

J Bacteriol· January 2011

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Identification of a novel trimeric autotransporter adhesin in the cryptic genospecies of Haemophilus.
Amanda J Sheets, Susan A Grass, Sara E Miller, Joseph W St Geme

J Bacteriol· June 2008

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