Publications by authors named "Amy M Beebe"

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Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Amy M Beebe

J Immunother Cancer· September 2022

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Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.
Selvakumar Sukumar, Douglas C Wilson, Ying Yu, Jerelyn Wong, Saraswathi Naravula, Amy M Beebe

Cancer Res· August 2017

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Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy.
Ashley E Mahne, Smita Mauze, Barbara Joyce-Shaikh, Jane Xia, Edward P Bowman, Amy M Beebe

Cancer Res· March 2017

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The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice.
Nicholas D Brunn, Smita Mauze, Danling Gu, Derek Wiswell, Roanna Ueda, Amy M Beebe

J Pharmacol Exp Ther· March 2016

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Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Judith T Murphy, Andre P Burey, Amy M Beebe, Danling Gu, Leonard G Presta

Blood· April 2014

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Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.
Jonathan M Pitt, Evangelos Stavropoulos, Paul S Redford, Amy M Beebe, Gregory J Bancroft

J Immunol· October 2012

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IL-10 elicits IFNγ-dependent tumor immune surveillance.
John B Mumm, Jan Emmerich, Xueqing Zhang, Ivan Chan, Lingling Wu, Amy M Beebe

Cancer Cell· December 2011

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The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).
Amy M Beebe, Daniel J Cua, Rene de Waal Malefyt

Cytokine Growth Factor Rev· March 2003

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