Publications by authors named "Amy Medlock"

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Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions.
Robert B Piel Iii, Chibuike D Obi, Martonio Ponte Viana, Mathilda M Willoughby, Osiris Martinez-Guzman, Amy E Medlock

J Inorg Biochem· February 2026

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Mechanisms of heme transport in the mitochondria.
Saieeda Fabia Ali, Adrianna E White, Amy Medlock, Oleh Khalimonchuk

Biochem Soc Trans· June 2025

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Direct Spectroscopic Ferrochelatase Assay.
Harry A Dailey, Amy E Medlock

Methods Mol Biol· July 2024

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Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations.
Mingshan Guo, Yuhong Lin, Chibuike David Obi, Peng Zhao, Harry A Dailey, Amy E Medlock

Int J Mol Sci· June 2024

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Exploring Academic Performance of Medical Students in an Integrated Hybrid Curriculum by Gender.
DeLoris Wenzel Hesse, Lynn M Ramsey, Lia Pierson Bruner, Claudia S Vega-Castillo, Dina Teshager, Amy E Medlock

Med Sci Educ· April 2023

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Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells.
Chibuike David Obi, Harry A Dailey, Yasaman Jami-Alahmadi, James A Wohlschlegel, Amy E Medlock

Life (Basel)· February 2023

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A primer on heme biosynthesis.
Harry A Dailey, Amy E Medlock

Biol Chem· November 2022

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New Avenues of Heme Synthesis Regulation.
Amy E Medlock, Harry A Dailey

Int J Mol Sci· July 2022

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Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria.
Chibuike David Obi, Tawhid Bhuiyan, Harry A Dailey, Amy E Medlock

Front Cell Dev Biol· May 2022

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Prime Real Estate: Metals, Cofactors and MICOS.
Amy E Medlock, J Catrice Hixon, Tawhid Bhuiyan, Paul A Cobine

Front Cell Dev Biol· May 2022

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The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors.
Jason R Marcero, James E Cox, Hector A Bergonia, Amy E Medlock, John D Phillips

Blood Adv· December 2021

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Ironing out the distribution of [2Fe-2S] motifs in ferrochelatases.
R Sophia Weerth, Amy E Medlock, Harry A Dailey

J Biol Chem· November 2021

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Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase.
Jonathan V Dietz, Mathilda M Willoughby, Robert B Piel, Teresa A Ross, Iryna Bohovych, Amy E Medlock

Redox Biol· October 2021

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Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase.
Amy E Medlock, Wided Najahi-Missaoui, Mesafint T Shiferaw, Angela N Albetel, William N Lanzilotta

Biochem J· September 2021

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Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites.
Osiris Martinez-Guzman, Mathilda M Willoughby, Arushi Saini, Jonathan V Dietz, Iryna Bohovych, Amy E Medlock

J Cell Sci· May 2020

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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme.
Samantha A Swenson, Courtney M Moore, Jason R Marcero, Amy E Medlock, Amit R Reddi

Cells· February 2020

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The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution.
Robert B Piel, Harry A Dailey, Amy E Medlock

Mol Genet Metab· November 2019

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Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis.
Joseph S Burch, Jason R Marcero, John Alan Maschek, James E Cox, Laurie K Jackson, Amy E Medlock

Blood· September 2018

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Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands.
Michael A Cahill, Amy E Medlock

J Steroid Biochem Mol Biol· July 2017

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A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.
Robert B Piel, Mesafint T Shiferaw, Ajay A Vashisht, Jason R Marcero, Jeremy L Praissman, Amy E Medlock

Biochemistry· September 2016

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Identification of the Mitochondrial Heme Metabolism Complex.
Amy E Medlock, Mesafint T Shiferaw, Jason R Marcero, Ajay A Vashisht, James A Wohlschlegel

PLoS One· May 2016

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Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Dhvanit I Shah, Naoko Takahashi-Makise, Jeffrey D Cooney, Liangtao Li, Iman J Schultz, Amy E Medlock

Nature· November 2012

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Identification and characterization of solvent-filled channels in human ferrochelatase.
Amy E Medlock, Wided Najahi-Missaoui, Teresa A Ross, Tamara A Dailey, Joseph Burch

Biochemistry· July 2012

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Product release rather than chelation determines metal specificity for ferrochelatase.
Amy E Medlock, Michael Carter, Tamara A Dailey, Harry A Dailey, William N Lanzilotta

J Mol Biol· October 2009

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A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase.
Amy E Medlock, Tamara A Dailey, Teresa A Ross, Harry A Dailey, William N Lanzilotta

J Mol Biol· November 2007

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