Publications by authors named "Andreas Hecht"

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TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids.
Yu-Hsiang Teng, Bismark Appiah, Geoffroy Andrieux, Monika Schrempp, Katja Rose, Andreas Hecht

Oncogenesis· May 2025

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Correction: Antón-García et al. TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation. 2023, , 588.
Pablo Antón-García, Elham Bavafaye Haghighi, Katja Rose, Georg Vladimirov, Melanie Boerries, Andreas Hecht

Cancers (Basel)· January 2024

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Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines.
Janna Fröhlich, Katja Rose, Andreas Hecht

Sci Rep· January 2023

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TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation.
Pablo Antón-García, Elham Bavafaye Haghighi, Katja Rose, Georg Vladimirov, Melanie Boerries, Andreas Hecht

Cancers (Basel)· January 2023

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Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT.
Marion Flum, Severin Dicks, Yu-Hsiang Teng, Monika Schrempp, Alexander Nyström, Andreas Hecht

Oncogene· March 2022

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SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.
Patrick Frey, Antoine Devisme, Katja Rose, Monika Schrempp, Vivien Freihen, Andreas Hecht

Oncogene· February 2022

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Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells.
Janna Wenzel, Katja Rose, Elham Bavafaye Haghighi, Constanze Lamprecht, Gilles Rauen, Andreas Hecht

Oncogene· May 2020

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SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation.
Vivien Freihen, Kerstin Rönsch, Justin Mastroianni, Patrick Frey, Katja Rose, Andreas Hecht

Int J Cancer· April 2020

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Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1.
Patrick Frey, Antoine Devisme, Monika Schrempp, Geoffroy Andrieux, Melanie Boerries, Andreas Hecht

Cancers (Basel)· April 2020

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Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells.
Sven Beyes, Geoffroy Andrieux, Monika Schrempp, David Aicher, Janna Wenzel, Andreas Hecht

Oncogene· October 2019

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SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.
Sabine Jägle, Hauke Busch, Vivien Freihen, Sven Beyes, Monika Schrempp, Andreas Hecht

PLoS Genet· November 2017

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ZEB1 is neither sufficient nor required for epithelial-mesenchymal transition in LS174T colorectal cancer cells.
Sabine Jägle, Annika Dertmann, Monika Schrempp, Andreas Hecht

Biochem Biophys Res Commun· January 2017

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Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.
Oskar Schnappauf, Sven Beyes, Annika Dertmann, Vivien Freihen, Patrick Frey, Andreas Hecht

Biochim Biophys Acta· November 2016

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Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics.
Uwe Benary, Bente Kofahl, Andreas Hecht, Jana Wolf

FEBS J· March 2015

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SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.
Kerstin Rönsch, Sabine Jägle, Katja Rose, Maximilian Seidl, Francis Baumgartner, Andreas Hecht

Mol Oncol· February 2015

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Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.
Sabine Jägle, Kerstin Rönsch, Sylvia Timme, Hana Andrlová, Miriam Bertrand, Andreas Hecht

Proc Natl Acad Sci U S A· April 2014

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Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex.
Susanne Elfert, Andreas Weise, Katja Bruser, Martin L Biniossek, Sabine Jägle, Andreas Hecht

PLoS One· November 2013

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Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions.
Uwe Benary, Bente Kofahl, Andreas Hecht, Jana Wolf

Front Physiol· March 2013

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Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.
Britta Wallmen, Monika Schrempp, Andreas Hecht

Nucleic Acids Res· October 2012

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Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions.
Katrin Luckert, Frank Götschel, Peter K Sorger, Andreas Hecht, Thomas O Joos

Mol Cell Proteomics· May 2011

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Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.
Kerstin Rönsch, Marcel Jäger, Anja Schöpflin, Mihai Danciu, Silke Lassmann, Andreas Hecht

Epigenetics· May 2011

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4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.
Rolf Gebhardt, Katja S Lerche, Frank Götschel, Robert Günther, Jens Kolander, Andreas Hecht

J Cell Mol Med· June 2010

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Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets.
Andreas Weise, Katja Bruser, Susanne Elfert, Britta Wallmen, Yvonne Wittel, Andreas Hecht

Nucleic Acids Res· April 2010

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Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes.
Tinneke Denayer, Morgane Locker, Caroline Borday, Tom Deroo, Sylvie Janssens, Andreas Hecht

Stem Cells· August 2008

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Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis.
Frank Götschel, Claudia Kern, Simona Lang, Titus Sparna, Cordula Markmann, Andreas Hecht

Exp Cell Res· April 2008

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