Publications by authors named "Andrew D Cansfield"

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Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Stacey M Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D Cansfield, Julie E Cansfield

ACS Med Chem Lett· November 2022

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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
Andrew D Cansfield, Mark A Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Julie E Cansfield

ACS Chem Neurosci· March 2022

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Structure-Based Drug Discovery of -(()-3-(7-Methyl-1-indazol-5-yl)-1-oxo-1-((()-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
Sarah J Bucknell, Mark A Ator, Alastair J H Brown, Jason Brown, Andrew D Cansfield, Julie E Cansfield

J Med Chem· July 2020

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CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
Andrew D Cansfield, Tammy Ladduwahetty, Mihiro Sunose, Katie Ellard, Rosemary Lynch

ACS Med Chem Lett· August 2016

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Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.
Simon F Scrace, Peter Kierstan, Jenifer Borgognoni, Lan-Zhen Wang, Sarah Denny, Andrew D Cansfield

Cell Cycle· December 2008

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Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Christine M Richardson, Douglas S Williamson, Martin J Parratt, Jenifer Borgognoni, Andrew D Cansfield

Bioorg Med Chem Lett· March 2006

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Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Douglas S Williamson, Martin J Parratt, Justin F Bower, Jonathan D Moore, Christine M Richardson, Andrew D Cansfield

Bioorg Med Chem Lett· February 2005

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Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain.
Christopher J Hobbs, Rino A Bit, Andrew D Cansfield, Bill Harris, Christopher H Hill

Bioorg Med Chem Lett· May 2002

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