Publications by authors named "Andrew D Hamilton"

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O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide.
Qian Zhang, Xiaohan Mei, Yan Li, Ziyang Wang, Ang Li, Andrew D Hamilton

Commun Biol· November 2025

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A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein-Protein Interaction Implicated in Breast Cancer.
James Luccarelli, Philip C Simister, Andrew D Hamilton, Stephan M Feller, Sam Thompson

Chembiochem· July 2025

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Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
Debabrata Maity, Yujeong Oh, Lothar Gremer, Wolfgang Hoyer, Mazin Magzoub, Andrew D Hamilton

Chemistry· July 2022

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Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
Debabrata Maity, Yujeong Oh, Lothar Gremer, Wolfgang Hoyer, Mazin Magzoub, Andrew D Hamilton

Chemistry· July 2022

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Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation.
Clementine E Bavinton, Rebecca Sternke-Hoffmann, Tohru Yamashita, Peter C Knipe, Andrew D Hamilton

Chem Commun (Camb)· April 2022

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Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications.
Nathalie Busschaert, Debabrata Maity, Pralok K Samanta, Niall J English, Andrew D Hamilton

Chembiochem· March 2022

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The helical supramolecular assembly of oligopyridylamide foldamers in aqueous media can be guided by adenosine diphosphates.
Debabrata Maity, Andrew D Hamilton

Chem Commun (Camb)· September 2021

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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.
L Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Andrew D Hamilton

Nat Commun· June 2021

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Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity.
Debabrata Maity, Madeline Howarth, Maria C Vogel, Mazin Magzoub, Andrew D Hamilton

J Am Chem Soc· March 2021

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Antimicrobial Peptide Mimetics Based on a Diphenylacetylene Scaffold: Synthesis, Conformational Analysis, and Activity.
Hayden Peacock, Sónia Troeira Henriques, Aurélie H Benfield, Alysha G Elliott, Jinghui Luo, Andrew D Hamilton

ChemMedChem· October 2020

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Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents.
Debabrata Maity, Sunil Kumar, Ruyof AlHussein, Lothar Gremer, Madeline Howarth, Andrew D Hamilton

RSC Chem Biol· October 2020

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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Andrew D Hamilton

Clin Cancer Res· October 2019

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Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers.
Joseph W Meisel, Chunhua T Hu, Andrew D Hamilton

Org Lett· October 2019

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α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA.
Debabrata Maity, Sunil Kumar, Francesca Curreli, Asim K Debnath, Andrew D Hamilton

Chemistry· May 2019

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Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.
Joseph W Meisel, Chunhua T Hu, Andrew D Hamilton

Org Lett· July 2018

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Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function.
Sunil Kumar, Anja Henning-Knechtel, Mazin Magzoub, Andrew D Hamilton

J Am Chem Soc· May 2018

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Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin.
Chul-Hwan Lee, Jia-Ray Yu, Sunil Kumar, Ying Jin, Gary LeRoy, Andrew D Hamilton

Mol Cell· May 2018

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Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation.
Sunil Kumar, Maria C Vogel, Andrew D Hamilton

Org Biomol Chem· January 2018

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Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity.
Sunil Kumar, Anja Henning-Knechtel, Ibrahim Chehade, Mazin Magzoub, Andrew D Hamilton

J Am Chem Soc· November 2017

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Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances.
James Luccarelli, Ian M Jones, Sam Thompson, Andrew D Hamilton

Org Biomol Chem· November 2017

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α-Helix Mimetics as Modulators of Aβ Self-Assembly.
Sunil Kumar, Andrew D Hamilton

J Am Chem Soc· April 2017

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An α-helical peptidomimetic scaffold for dynamic combinatorial library formation.
Nathalie Busschaert, Sam Thompson, Andrew D Hamilton

Chem Commun (Camb)· December 2016

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Non-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation.
Hayden Peacock, Jinghui Luo, Tohru Yamashita, James Luccarelli, Sam Thompson, Andrew D Hamilton

Chem Sci· October 2016

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Acid-mediated topological control in a functionalized foldamer.
Peter C Knipe, Sam Thompson, Andrew D Hamilton

Chem Commun (Camb)· May 2016

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A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics.
Tohru Yamashita, Peter C Knipe, Nathalie Busschaert, Sam Thompson, Andrew D Hamilton

Chemistry· October 2015

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