Publications by authors named "Andrew D Rowan"

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SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis.
Matthew J Barter, David A Turner, Sarah J Rice, Mary Hines, Hua Lin, Andrew D Rowan

Matrix Biol· November 2024

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Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
David J Wilkinson, Adrian M D Falconer, Helen L Wright, Hua Lin, Kazuhiro Yamamoto, Andrew D Rowan

FEBS J· January 2022

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Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib.
Tariq Al Shehri, Kimberly Gilmour, Florian Gothe, Sam Loughlin, Shahnaz Bibi, Andrew D Rowan

J Clin Immunol· November 2019

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Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover.
Adrian M D Falconer, Chun Ming Chan, Joseph Gray, Izuru Nagashima, Robert A Holland, Andrew D Rowan

J Biol Chem· June 2019

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Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes.
Christopher D Macdonald, Adrian M D Falconer, Chun Ming Chan, David J Wilkinson, Andrew Skelton, Andrew D Rowan

PLoS One· April 2019

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Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics.
David J Wilkinson, Maria Del Carmen Arques, Carmen Huesa, Andrew D Rowan

Br J Pharmacol· January 2019

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Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.
David Hodgson, Andrew D Rowan, Francesco Falciani, Carole J Proctor

PLoS Comput Biol· January 2019

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Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.
Jonathan Baker, Adrian M D Falconer, David J Wilkinson, G Nicholas Europe-Finner, Gary J Litherland, Andrew D Rowan

PLoS One· July 2018

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The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.
David J Wilkinson, Antoine Desilets, Hua Lin, Sarah Charlton, Maria Del Carmen Arques, Andrew D Rowan

Sci Rep· December 2017

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Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.
David J Wilkinson, Hui Wang, Angela Habgood, Heather K Lamb, Paul Thompson, Andrew D Rowan

Arthritis Rheumatol· August 2017

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Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.
Chun Ming Chan, Christopher D Macdonald, Gary J Litherland, David J Wilkinson, Andrew Skelton, Andrew D Rowan

J Biol Chem· February 2017

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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology.
Carmen Huesa, Ana C Ortiz, Lynette Dunning, Laura McGavin, Louise Bennett, Andrew D Rowan

Ann Rheum Dis· November 2016

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Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts.
Rachel C Williams, Andrew J Skelton, Stephen M Todryk, Andrew D Rowan, Philip M Preshaw

PLoS One· July 2016

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Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Wang Hui, David A Young, Andrew D Rowan, Xin Xu, Tim E Cawston

Ann Rheum Dis· February 2016

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Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).
Jie Zheng, Frank L van de Veerdonk, Katherine L Crossland, Sanne P Smeekens, Chun M Chan, Andrew D Rowan

Eur J Immunol· October 2015

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Tribbles and arthritis: what are the links?
Andrew D Rowan, Gary J Litherland

Biochem Soc Trans· October 2015

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Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.
Marta Radwan, David J Wilkinson, Wang Hui, Auriane P M Destrument, Sarah H Charlton, Andrew D Rowan

Ann Rheum Dis· August 2015

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Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.
Gary J Litherland, Wang Hui, Martina S Elias, David J Wilkinson, Sharon Watson, Andrew D Rowan

Arthritis Rheumatol· August 2014

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Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation.
Marzena Ciechomska, Caroline L Wilson, Achilleas Floudas, Wang Hui, Andrew D Rowan

Immunology· January 2014

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Macrophage migration and invasion is regulated by MMP10 expression.
Megan Y Murray, Timothy P Birkland, Jonathan D Howe, Andrew D Rowan, Mark Fidock

PLoS One· December 2013

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Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.
Kirsty L Culley, Wang Hui, Matt J Barter, Rose K Davidson, Tracey E Swingler, Andrew D Rowan

Arthritis Rheum· July 2013

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Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes.
Marta Radwan, Christos Gavriilidis, John H Robinson, Rose Davidson, Ian M Clark, Andrew D Rowan

Arthritis Rheum· May 2013

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cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.
Catherine Bui, Matt J Barter, Jenny L Scott, Yaobo Xu, Martin Galler, Andrew D Rowan

FASEB J· July 2012

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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.
Wang Hui, Gary J Litherland, Martina S Elias, Gareth I Kitson, Tim E Cawston, Andrew D Rowan

Ann Rheum Dis· March 2012

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Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.
Wang Hui, Gary J Litherland, Matthew Jefferson, Matt J Barter, Martina S Elias, Andrew D Rowan

Rheumatology (Oxford)· November 2010

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