Publications by authors named "Andrew G Edwards"

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The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner.
Lynn C Lunsonga, Mohammad Fatehi, Wentong Long, Amy J Barr, Brittany Gruber, Andrew G Edwards

J Mol Cell Cardiol· January 2025

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Mechanisms of spontaneous Ca release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation.
Xianwei Zhang, Haibo Ni, Stefano Morotti, Charlotte E R Smith, Daisuke Sato, Andrew G Edwards

J Physiol· July 2023

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Mechanisms of spontaneous Ca release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca -handling protein variation.
Xianwei Zhang, Charlotte E R Smith, Stefano Morotti, Andrew G Edwards, Daisuke Sato

J Physiol· July 2023

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Gating kinetics and pharmacological properties of small-conductance Ca-activated potassium channels.
Ilsbeth G M van Herck, Vincent Seutin, Bo H Bentzen, Neil V Marrion, Andrew G Edwards

Biophys J· April 2023

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Assessing Endometriosis during Routine Gynaecological Ultrasound: The Road Less Traveled.
Sofie Piessens, Andrew G Edwards

J Minim Invasive Gynecol· October 2022

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Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.
Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Andrew G Edwards

Elife· August 2022

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Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System.
Verena Charwat, Bérénice Charrez, Brian A Siemons, Henrik Finsberg, Karoline H Jæger, Andrew G Edwards

ACS Pharmacol Transl Sci· August 2022

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Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips.
Nathaniel Huebsch, Berenice Charrez, Gabriel Neiman, Brian Siemons, Steven C Boggess, Andrew G Edwards

Nat Biomed Eng· April 2022

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Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve.
Karoline Horgmo Jæger, Andrew G Edwards, Wayne R Giles, Aslak Tveito

Sci Rep· April 2022

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Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
William E Louch, Harmonie Perdreau-Dahl, Andrew G Edwards

Front Physiol· March 2022

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Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.
Stefano Morotti, Caroline Liu, Bence Hegyi, Haibo Ni, Alex Fogli Iseppe, Andrew G Edwards

Sci Adv· November 2021

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Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse.
Andrew G Edwards, Halvor Mørk, Mathis K Stokke, David B Lipsett, Ivar Sjaastad

Front Physiol· October 2021

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From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology.
Karoline Horgmo Jæger, Andrew G Edwards, Wayne R Giles, Aslak Tveito

Front Physiol· October 2021

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Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning.
Alex Fogli Iseppe, Haibo Ni, Sicheng Zhu, Xianwei Zhang, Raffaele Coppini, Andrew G Edwards

Clin Pharmacol Ther· August 2021

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A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes.
Karoline Horgmo Jæger, Andrew G Edwards, Wayne R Giles, Aslak Tveito

PLoS Comput Biol· August 2021

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Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics.
Bérénice Charrez, Verena Charwat, Brian A Siemons, Ishan Goswami, Courtney Sakolish, Andrew G Edwards

Front Pharmacol· August 2021

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In vitro safety "clinical trial" of the cardiac liability of drug polytherapy.
Bérénice Charrez, Verena Charwat, Brian Siemons, Henrik Finsberg, Evan W Miller, Andrew G Edwards

Clin Transl Sci· May 2021

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In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy.
Bérénice Charrez, Verena Charwat, Brian Siemons, Henrik Finsberg, Evan Miller, Andrew G Edwards

bioRxiv· December 2020

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Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K -current block in atrial fibrillation.
Haibo Ni, Alex Fogli Iseppe, Wayne R Giles, Sanjiv M Narayan, Henggui Zhang, Andrew G Edwards

Br J Pharmacol· October 2020

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A unified computational model for cortical post-synaptic plasticity.
Tuomo Mäki-Marttunen, Nicolangelo Iannella, Andrew G Edwards, Gaute T Einevoll, Kim T Blackwell

Elife· July 2020

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Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes.
Kiarash Tazmini, Michael Frisk, Alexandre Lewalle, Martin Laasmaa, Stefano Morotti, Andrew G Edwards

Circ Res· March 2020

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General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Zhihua Li, Gary R Mirams, Takashi Yoshinaga, Bradley J Ridder, Xiaomei Han, Andrew G Edwards

Clin Pharmacol Ther· January 2020

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Arrhythmogenic Current Generation by Myofilament-Triggered Ca Release and Sarcomere Heterogeneity.
Viviane Timmermann, Andrew G Edwards, Samuel T Wall, Joakim Sundnes, Andrew D McCulloch

Biophys J· December 2019

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Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.
Tuomo Mäki-Marttunen, Tobias Kaufmann, Torbjørn Elvsåshagen, Anna Devor, Srdjan Djurovic, Andrew G Edwards

Front Psychiatry· August 2019

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Properties of cardiac conduction in a cell-based computational model.
Karoline Horgmo Jæger, Andrew G Edwards, Andrew McCulloch, Aslak Tveito

PLoS Comput Biol· May 2019

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