Publications by authors named "Andrew Lowell"

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Annulation Methods toward the Total Synthesis of Thermorubin: Construction of the AB and BCD Ring Systems.
Zachary A Kohanov, Andrew N Lowell

J Org Chem· August 2025

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Inherent antibacterial properties of mannose-containing polynorbornene glycomaterials.
Brady A Hall, Ophelia J Wadsworth, Logan M Breiner, Jacob C Chappell, Andrew S Brenner, Andrew N Lowell

Chem Commun (Camb)· March 2025

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Gas-Phase Unfolding Reveals Stability Shifts Associated with Substrate Binding in Modular Polyketide Synthases.
Chunyi Zhao, Nicholas B Borotto, Jennifer Schmidt, Kinshuk Srivastava, Andrew Lowell

J Am Soc Mass Spectrom· February 2025

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Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques.
Alessandro Fracassi, Hui Qiao, Andrew N Lowell, Jianbo Cao, Jeffrey W Bode

ACS Pharmacol Transl Sci· February 2025

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Highly Active Oligoethylene Glycol Pleuromutilins via Systematic Linker Synthesis/One-Pot Attachment and a Microscale Solubility Method.
Logan M Breiner, Roman P Slowinski, Andrew N Lowell

J Org Chem· January 2025

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Regioselective Annulation of 6-Carboxy-Substituted Pyrones as a Two-Carbon Unit in Formal [4 + 2] Cycloaddition Reactions.
Zachary A Kohanov, Suzzudul Islam Shuvo, Andrew N Lowell

J Org Chem· July 2024

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Forgotten Natural Products: Semisynthetic Development of Blasticidin S As an Antibiotic Lead.
Cole Gannett, Kateland Tiller, Anthony J Briganti, Anne M Brown, James Weger-Lucarelli, Andrew N Lowell

ACS Med Chem Lett· March 2024

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Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like Scenarios.
Samrendra K Singh, Kelsie King, Cole Gannett, Christina Chuong, Soumil Y Joshi, Andrew N Lowell

J Phys Chem Lett· October 2023

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Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity.
Cole Gannett, Paige Banks, Christina Chuong, James Weger-Lucarelli, Emily Mevers, Andrew N Lowell

RSC Med Chem· April 2023

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Thermorubin Biosynthesis Initiated by a Salicylate Synthase Suggests an Unusual Conversion of Phenols to Pyrones.
Jennifer P McCord, Zachary A Kohanov, Andrew N Lowell

ACS Chem Biol· November 2022

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Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Elinor Breiner-Goldstein, Zohar Eyal, Donna Matzov, Yehuda Halfon, Giuseppe Cimicata, Andrew N Lowell

Nucleic Acids Res· September 2021

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Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase.
Edward Kalkreuter, Kyle S Bingham, Aaron M Keeler, Andrew N Lowell, Jennifer J Schmidt

Nat Commun· April 2021

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Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis.
Robert M Hohlman, Sean A Newmister, Jacob N Sanders, Yogan Khatri, Shasha Li, Andrew N Lowell

ACS Catal· April 2021

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Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.
Aaron A Koch, Jennifer J Schmidt, Andrew N Lowell, Douglas A Hansen, Katherine M Coburn

Angew Chem Int Ed Engl· August 2020

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Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids.
Yogan Khatri, Robert M Hohlman, Johnny Mendoza, Shasha Li, Andrew N Lowell

ACS Synth Biol· June 2020

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Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases.
Shasha Li, Sean A Newmister, Andrew N Lowell, Jiachen Zi, Callie R Chappell

Angew Chem Int Ed Engl· May 2020

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Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.
Samuel T Slocum, Andrew N Lowell, Ashootosh Tripathi, Vikram V Shende, Janet L Smith

Methods Enzymol· April 2019

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Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.
Edward Kalkreuter, Jared M CroweTipton, Andrew N Lowell, David H Sherman, Gavin J Williams

J Am Chem Soc· February 2019

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Larger Substituents on Amide Cavitands Induce Bigger Cavities.
Safwan Aroua, Andrew N Lowell, Ankita Ray, Nils Trapp, W Bernd Schweizer

Org Lett· January 2019

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Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.
Meredith A Skiba, Andrew P Sikkema, Nathan A Moss, Andrew N Lowell, Min Su

ACS Chem Biol· June 2018

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Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.
Sean A Newmister, Shasha Li, Marc Garcia-Borràs, Jacob N Sanders, Song Yang, Andrew N Lowell

Nat Chem Biol· April 2018

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Assessing the risk of hypercalcemic crisis in patients with primary hyperparathyroidism.
Andrew J Lowell, Norah M Bushman, Xing Wang, Yue Ma, Susan C Pitt

J Surg Res· September 2017

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Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.
Andrew N Lowell, Matthew D DeMars, Samuel T Slocum, Fengan Yu, Krithika Anand

J Am Chem Soc· June 2017

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Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
Shasha Li, Andrew N Lowell, Sean A Newmister, Fengan Yu, Robert M Williams

Nat Chem Biol· May 2017

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Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.
Irina Koryakina, Christian Kasey, John B McArthur, Andrew N Lowell, Joseph A Chemler

ACS Chem Biol· January 2017

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