Publications by authors named "Andrew Rech"

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SPACEc: a streamlined, interactive Python workflow for multiplexed image processing and analysis.
Yuqi Tan, Tim N Kempchen, Martin Becker, Maximilian Haist, Dorien Feyaerts, Andrew J Rech

Nat Commun· November 2025

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Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial.
Stephen J Bagley, Arati S Desai, Joseph A Fraietta, Dana Silverbush, Daniel Chafamo, Andrew J Rech

Nat Med· September 2025

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Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer.
M Angela Aznar, Charly R Good, Julie S Barber-Rotenberg, Sangya Agarwal, Wesley Wilson, Andrew J Rech

Cell Rep Med· September 2025

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Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial.
Stephen J Bagley, Arati S Desai, Joseph A Fraietta, Dana Silverbush, Daniel Chafamo, Andrew J Rech

Nat Med· August 2025

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Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways.
David Smith, Anna Eichinger, Éanna Fennell, Zijun Y Xu-Monette, Andrew Rech

Nat Commun· July 2025

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Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure.
Jakub Svoboda, Daniel J Landsburg, James Gerson, Sunita D Nasta, Stefan K Barta, Andrew Rech

N Engl J Med· May 2025

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Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer.
Yuwei Zhang, Shahira Abousamra, Mahmudul Hasan, Luke Torre-Healy, Spencer Krichevsky, Andrew J Rech

Res Sq· April 2025

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Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors.
Adham S Bear, Rebecca B Nadler, Mark H O'Hara, Kelsey L Stanton, Chong Xu, Andrew J Rech

J Clin Invest· September 2024

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Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine Pathways.
David Smith, Anna Eichinger, Andrew Rech, Julia Wang, Eduardo Esteva

bioRxiv· September 2024

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T cell-mediated curation and restructuring of tumor tissue coordinates an effective immune response.
John W Hickey, Maximillian Haist, Nina Horowitz, Chiara Caraccio, Yuqi Tan, Andrew J Rech

Cell Rep· December 2023

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Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.
Sangya Agarwal, M Angela Aznar, Andrew J Rech, Charly R Good, Shunichiro Kuramitsu

Immunity· October 2023

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Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction.
In-Young Jung, Robert L Bartoszek, Andrew J Rech, Sierra M Collins, Soon-Keat Ooi

Cancer Discov· July 2023

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BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion.
In-Young Jung, Vivek Narayan, Sierra McDonald, Andrew J Rech, Robert Bartoszek

Sci Transl Med· November 2022

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A real-time GPU-accelerated parallelized image processor for large-scale multiplexed fluorescence microscopy data.
Guolan Lu, Marc A Baertsch, John W Hickey, Yury Goltsev, Andrew J Rech

Front Immunol· October 2022

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T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma.
Maryam Barsch, Henrike Salié, Alexandra Emilia Schlaak, Zhen Zhang, Moritz Hess, Andrew Rech

J Hepatol· August 2022

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PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial.
Vivek Narayan, Julie S Barber-Rotenberg, In-Young Jung, Simon F Lacey, Andrew J Rech

Nat Med· April 2022

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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.
Daniel K Wells, Marit M van Buuren, Kristen K Dang, Vanessa M Hubbard-Lucey, Kathleen C F Sheehan, Andrew J Rech

Cell· October 2020

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Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade.
Lee P Richman, Robert H Vonderheide, Andrew J Rech

Cell Syst· October 2019

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Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer.
Adam A Kraya, Kara N Maxwell, Bradley Wubbenhorst, Brandon M Wenz, John Pluta, Andrew J Rech

Clin Cancer Res· July 2019

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Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2).
Nune Markosyan, Jinyang Li, Yu H Sun, Lee P Richman, Jeffrey H Lin, Andrew J Rech

J Clin Invest· June 2019

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Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint Blockade in Cancer.
Andrew J Rech, Hannah Dada, Jonathan J Kotzin, Jorge Henao-Mejia, Andy J Minn

Cancer Res· August 2018

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Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy.
Jinyang Li, Katelyn T Byrne, Fangxue Yan, Taiji Yamazoe, Zeyu Chen, Andrew J Rech

Immunity· July 2018

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Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer.
Andrew J Rech, David Balli, Alejandro Mantero, Hemant Ishwaran, Katherine L Nathanson

Cancer Immunol Res· March 2018

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Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.
Roberto Calcedo, Suryanarayan Somanathan, Qiuyue Qin, Michael R Betts, Andrew J Rech

Proc Natl Acad Sci U S A· February 2017

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T-Cell Transfer Therapy Targeting Mutant KRAS.
Andrew J Rech, Robert H Vonderheide

N Engl J Med· February 2017

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