Publications by authors named "Andrew Siwkowski"

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C
Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.
Punit P Seth, Charles R Allerson, Andrew Siwkowski, Guillermo Vasquez, Andres Berdeja

J Med Chem· December 2010

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Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.
Punit P Seth, Andrew Siwkowski, Charles R Allerson, Guillermo Vasquez, Sam Lee

Nucleic Acids Symp Ser (Oxf)· November 2010

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An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
Punit P Seth, Charles R Allerson, Andres Berdeja, Andrew Siwkowski, Pradeep S Pallan

J Am Chem Soc· October 2010

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Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
Jozsef Karman, Jennifer L Tedstone, Nathan K Gumlaw, Yunxiang Zhu, Nelson Yew, Andrew Siwkowski

Int Immunol· July 2010

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Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.
Edward V Wancewicz, Martin A Maier, Andrew M Siwkowski, Klaus Albertshofer, Theodore M Winger

J Med Chem· May 2010

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Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.
Thazha P Prakash, Andrew Siwkowski, Charles R Allerson, Michael T Migawa, Sam Lee

J Med Chem· February 2010

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Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2'-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN.
Richard S Geary, Ed Wancewicz, John Matson, Megan Pearce, Andrew Siwkowski

Biochem Pharmacol· August 2009

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Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.
Punit P Seth, Andrew Siwkowski, Charles R Allerson, Guillermo Vasquez, Sam Lee

J Med Chem· January 2009

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals.
Eric E Swayze, Andrew M Siwkowski, Edward V Wancewicz, Michael T Migawa, Tadeusz K Wyrzykiewicz

Nucleic Acids Res· March 2007

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Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.
Walt F Lima, John B Rose, Josh G Nichols, Hongjiang Wu, Michael T Migawa, Andrew M Siwkowski

Mol Pharmacol· January 2007

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Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids.
Martin A Maier, Christine C Esau, Andrew M Siwkowski, Edward V Wancewicz, Klaus Albertshofer

J Med Chem· April 2006

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Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid.
Klaus Albertshofer, Andrew M Siwkowski, Edward V Wancewicz, Christine C Esau, Tanya Watanabe

J Med Chem· October 2005

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Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression.
Andrew M Siwkowski, Lisa A Madge, Seongjoon Koo, Erin L McMillan, Brett P Monia

Mol Pharmacol· September 2004

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Design, targeting, and initial screening of sTRSV-derived hairpin ribozymes for optimum helix 1 length and catalytic efficiency in vitro.
Max W Richardson, Linda Hostalek, Michelle Dobson, Jason Hu, Richard Shippy, Andrew Siwkowski

Methods Mol Biol· June 2004

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Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing.
Andrew M Siwkowski, Leila Malik, Christine C Esau, Martin A Maier, Edward V Wancewicz

Nucleic Acids Res· June 2004

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Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.
Lijiang Shen, Andrew Siwkowski, Edward V Wancewicz, Elena Lesnik, Madeline Butler

Antisense Nucleic Acid Drug Dev· April 2004

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Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis.
Kathleen J Myers, Sreekant Murthy, Anne Flanigan, Donna R Witchell, Madeline Butler, Andrew Siwkowski

J Pharmacol Exp Ther· January 2003

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