Publications by authors named "Andy Sykes"

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Camizestrant in Combination with Three Globally Approved CDK4/6 Inhibitors in Women with ER+, HER2- Advanced Breast Cancer: Results from SERENA-1.
Richard D Baird, Begoña Bermejo de Las Heras, Manuel Ruiz-Borrego, Christos Vaklavas, Irene Moreno, Andy Sykes

Clin Cancer Res· October 2025

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The application of mechanistic absorption, distribution, metabolism and excretion studies and physiologically-based pharmacokinetic modeling in the discovery of the next-generation oral selective estrogen receptor degrader camizestrant to achieve an acceptable human pharmacokinetic profile.
Eric T Gangl, Roshini Markandu, Pradeep Sharma, Andy Sykes, Petar Pop-Damkov

Drug Metab Dispos· August 2025

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Achieving human brain exposure with the oral ataxia-telangiectasia mutated kinase inhibitor AZD1390, a substrate of aldehyde oxidase.
Nicola Colclough, Alexandra L Orton, Scott Martin, Martin Wild, Venkatesh Pilla Reddy, Andy Sykes

Drug Metab Dispos· August 2025

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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
Kurt G Pike, Thomas A Hunt, Bernard Barlaam, David Benstead, Elaine Cadogan, Andy Sykes

J Med Chem· February 2024

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Machine Learning Models for Human Pharmacokinetic Parameters with In-House Validation.
Filip Miljković, Anton Martinsson, Olga Obrezanova, Beth Williamson, Martin Johnson, Andy Sykes

Mol Pharm· December 2021

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Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.
Aurelija Jucaite, Per Stenkrona, Zsolt Cselényi, Serena De Vita, Nuria Buil-Bruna, Andy Sykes

Neuro Oncol· April 2021

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Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice.
Tomoki Yoneyama, Sho Sato, Andy Sykes, Rosa Fradley, Stuart Stafford

Pharm Res· August 2020

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Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader.
Tashinga E Bapiro, Andy Sykes, Scott Martin, Michael Davies, James W T Yates

Drug Metab Dispos· September 2018

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An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects.
Borut Cizman, Andy P Sykes, Gitanjali Paul, Steven Zeig, Alexander R Cobitz

Kidney Int Rep· July 2018

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Assessment of the Target Engagement and D-Serine Biomarker Profiles of the D-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756.
Eimear Howley, Michael Bestwick, Rosa Fradley, Helen Harrison, Mathew Leveridge, Andy P Sykes

Neurochem Res· November 2017

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A European inventory of data elements for patient recruitment.
Justin Doods, Caroline Lafitte, Nadine Ulliac-Sagnes, Johan Proeve, Florence Botteri, Andy Sykes

Stud Health Technol Inform· November 2016

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Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing.
Taku Sakurai, Richard Davenport, Stuart Stafford, Johannes Grosse, Kazumasa Ogawa, Andy Sykes

Eur J Pharmacol· March 2014

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