Publications by authors named "Angeline M Lyon"

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C
Cryo-EM structure of phospholipase Cε defines N-terminal domains and their roles in activity.
Kadidia Samassekou, Elisabeth E Garland-Kuntz, Vaani Ohri, Isaac J Fisher, Satchal K Erramilli, Angeline M Lyon

Commun Biol· October 2025

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RhoA allosterically activates phospholipase Cε via its EF hands.
Vaani Ohri, Kadidia Samassekou, Kaushik Muralidharan, Elisabeth E Garland-Kuntz, Isaac J Fisher, Angeline M Lyon

Commun Biol· September 2025

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RhoA Allosterically Activates Phospholipase Cε via its EF Hands.
Vaani Ohri, Kadidia Samassekou, Kaushik Muralidharan, Elisabeth E Garland-Kuntz, Isaac J Fisher, Angeline M Lyon

bioRxiv· June 2025

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An integrated mechanism of G regulation of PLCβ enzymes.
Kanishka Senarath, Isaac J Fisher, Wonjo Jang, Sumin Lu, Asuka Inoue, Angeline M Lyon

Proc Natl Acad Sci U S A· April 2025

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Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity.
Kadidia Samassekou, Elisabeth E Garland-Kuntz, Vaani Ohri, Isaac J Fisher, Satchal K Erramilli, Angeline M Lyon

bioRxiv· September 2024

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Structure and regulation of phospholipase Cβ and ε at the membrane.
Kaushik Muralidharan, Michelle M Van Camp, Angeline M Lyon

Chem Phys Lipids· March 2021

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Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A.
Monita Sieng, Arielle F Selvia, Elisabeth E Garland-Kuntz, Jesse B Hopkins, Isaac J Fisher, Angeline M Lyon

J Biol Chem· December 2020

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Q's the Boss: Gα Regulates G-Mediated Calcium Release through PLCβ.
Isaac J Fisher, Angeline M Lyon

Mol Cell· December 2020

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Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements.
Ngango Y Rugema, Elisabeth E Garland-Kuntz, Monita Sieng, Kaushik Muralidharan, Michelle M Van Camp, Angeline M Lyon

Commun Biol· August 2020

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Corrigendum to "Intramolecular Electrostatic Interactions Contribute to Phospholipase Cβ3 Autoinhibition" [Cellular signaling 62 (2019) Epub ahead of print].
Candi M Esquina, Elisabeth E Garland-Kuntz, Daniel Goldfarb, Emily K McDonald, Brianna N Hudson, Angeline M Lyon

Cell Signal· November 2019

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Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition.
Candi M Esquina, Elisabeth E Garland-Kuntz, Daniel Goldfarb, Emily K McDonald, Brianna N Hudson, Angeline M Lyon

Cell Signal· October 2019

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Gα and the Phospholipase Cβ3 X-Y Linker Regulate Adsorption and Activity on Compressed Lipid Monolayers.
Brianna N Hudson, Rachel E Jessup, Keshav K Prahalad, Angeline M Lyon

Biochemistry· August 2019

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Quantifying Acute Fuel and Respiration Dependent pH Homeostasis in Live Cells Using the mCherryTYG Mutant as a Fluorescence Lifetime Sensor.
Emily P Haynes, Megha Rajendran, Chace K Henning, Abhipri Mishra, Angeline M Lyon

Anal Chem· July 2019

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High-resolution structure of RGS17 suggests a role for Ca in promoting the GTPase-activating protein activity by RZ subfamily members.
Monita Sieng, Michael P Hayes, Joseph B O'Brien, C Andrew Fowler, Jon C Houtman, Angeline M Lyon

J Biol Chem· May 2019

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Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation.
Elisabeth E Garland-Kuntz, Frank S Vago, Monita Sieng, Michelle Van Camp, Srinivas Chakravarthy, Angeline M Lyon

J Biol Chem· November 2018

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G protein βγ subunits directly interact with and activate phospholipase Cϵ.
Jerry C Madukwe, Elisabeth E Garland-Kuntz, Angeline M Lyon, Alan V Smrcka

J Biol Chem· April 2018

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Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate.
Brianna N Hudson, Seok-Hee Hyun, David H Thompson, Angeline M Lyon

Biochemistry· October 2017

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Molecular mechanisms of phospholipase C β3 autoinhibition.
Angeline M Lyon, Jessica A Begley, Taylor D Manett, John J G Tesmer

Structure· December 2014

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Strike a pose: Gαq complexes at the membrane.
Angeline M Lyon, Veronica G Taylor, John J G Tesmer

Trends Pharmacol Sci· January 2014

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Structural insights into phospholipase C-β function.
Angeline M Lyon, John J G Tesmer

Mol Pharmacol· October 2013

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Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.
Angeline M Lyon, Somnath Dutta, Cassandra A Boguth, Georgios Skiniotis, John J G Tesmer

Nat Struct Mol Biol· March 2013

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An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.
Angeline M Lyon, Valerie M Tesmer, Vishan D Dhamsania, David M Thal, Joanne Gutierrez

Nat Struct Mol Biol· August 2011

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Bruno protein contains an expanded RNA recognition motif.
Angeline M Lyon, Brad S Reveal, Paul M Macdonald, David W Hoffman

Biochemistry· December 2009

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