Publications by authors named "Angus D Cowan"

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Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Michelle S Miller, Angus D Cowan, Jason M Brouwer, Sean T Smyth, Liuyu Peng

FEBS J· June 2024

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Targeted protein degradation via intramolecular bivalent glues.
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida

Nature· March 2024

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Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory.
Angus D Cowan, Alessio Ciulli

Annu Rev Biochem· June 2022

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The Bak core dimer focuses triacylglycerides in the membrane.
Nicholas A Smith, Ahmad Z Wardak, Angus D Cowan, Peter M Colman, Peter E Czabotar

Biophys J· February 2022

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Satomi Imaide, Kristin M Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Angus D Cowan

Nat Chem Biol· November 2021

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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Angus D Cowan

Nat Commun· November 2021

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BAK core dimers bind lipids and can be bridged by them.
Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam

Nat Struct Mol Biol· November 2020

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Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.
Catia L Pierotti, Maria C Tanzer, Annette V Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Angus D Cowan

ACS Chem Biol· October 2020

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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Emma J Petrie, Jarrod J Sandow, Annette V Jacobsen, Brian J Smith, Michael D W Griffin, Angus D Cowan

Nat Commun· June 2018

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Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Francine F S Ke, Hannah K Vanyai, Angus D Cowan, Alex R D Delbridge, Lachlan Whitehead

Cell· May 2018

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Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw

Mol Cell· November 2017

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