Publications by authors named "Angus M Sinclair"

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IGM-7354, an Immunocytokine with IL15 Fused to an Anti-PD-L1 IgM, Induces NK and CD8+ T cell-Mediated Cytotoxicity of PD-L1-Positive Tumor Cells.
Mélanie Desbois, Thierry Giffon, Poonam Yakkundi, Carolyn R Denson, Keerthana Sekar, Angus M Sinclair

Cancer Immunol Res· August 2025

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Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199.
Beatrice T Wang, Tasnim Kothambawala, Ling Wang, Thomas J Matthew, Susan E Calhoun, Angus M Sinclair

Mol Cancer Ther· December 2021

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Structure, Function, and Therapeutic Use of IgM Antibodies.
Bruce A Keyt, Ramesh Baliga, Angus M Sinclair, Stephen F Carroll, Marvin S Peterson

Antibodies (Basel)· October 2020

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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Swetha Raman, Melissa Beilschmidt, Minh To, Kevin Lin, Francine Lui, Angus M Sinclair

Proc Natl Acad Sci U S A· April 2019

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The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk.
Kimberly H Harrington, Chelsea J Gudgeon, George S Laszlo, Kathryn J Newhall, Angus M Sinclair

PLoS One· May 2016

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Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia.
Patricia L McElroy, Ping Wei, Keri Buck, Angus M Sinclair, Michael Eschenberg

Exp Hematol· June 2015

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Characterization of bispecific T-cell Engager (BiTE) antibodies with a high-capacity T-cell dependent cellular cytotoxicity (TDCC) assay.
Aaron A Nazarian, Ivonne L Archibeque, Yen H Nguyen, Paul Wang, Angus M Sinclair

J Biomol Screen· April 2015

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Dose-related differences in the pharmacodynamic and toxicologic response to a novel hyperglycosylated analog of recombinant human erythropoietin in Sprague-Dawley rats with similarly high hematocrit.
Dina A Andrews, Babette M Boren, James R Turk, Rogely W Boyce, Yudong D He, Angus M Sinclair

Toxicol Pathol· December 2014

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Cytokines associated with increased erythropoiesis in Sprague-Dawley rats administered a novel hyperglycosylated analog of recombinant human erythropoietin.
Dina A Andrews, Hisham K Hamadeh, Yudong D He, Babette M Boren, James R Turk, Angus M Sinclair

Toxicol Pathol· December 2014

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Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML.
George S Laszlo, Chelsea J Gudgeon, Kimberly H Harrington, Justine Dell'Aringa, Kathryn J Newhall, Angus M Sinclair

Blood· January 2014

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Erythropoiesis stimulating agents: approaches to modulate activity.
Angus M Sinclair

Biologics· July 2013

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The effect of erythropoietin on normal and neoplastic cells.
Steve Elliott, Angus M Sinclair

Biologics· October 2012

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Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells.
Angus M Sinclair, Angela Coxon, Ian McCaffery, Stephen Kaufman, Katherine Paweletz

Blood· May 2010

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Absence of functional EpoR expression in human tumor cell lines.
Susan Swift, Aaron R Ellison, Paul Kassner, Ian McCaffery, John Rossi, Angus M Sinclair

Blood· May 2010

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Erythropoietin receptor in ovarian cancer cells - Letter.
Susan E Swift, Steve Elliott, Angus M Sinclair, C Glenn Begley

Mol Cancer Ther· April 2010

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Expression and function of erythropoietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients.
Angus M Sinclair, Marque D Todd, Kevin Forsythe, Susan J Knox, Steve Elliott

Cancer· August 2007

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Anti-Epo receptor antibodies do not predict Epo receptor expression.
Steve Elliott, Leigh Busse, Michael B Bass, Hsieng Lu, Ildiko Sarosi, Angus M Sinclair

Blood· March 2006

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Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins.
Angus M Sinclair, Steve Elliott

J Pharm Sci· August 2005

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Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.
Thomas Hiesberger, Yun Bai, Xinli Shao, Brian T McNally, Angus M Sinclair

J Clin Invest· March 2004

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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
Fangming Lin, Thomas Hiesberger, Kimberly Cordes, Angus M Sinclair, Lawrence S B Goldstein

Proc Natl Acad Sci U S A· April 2003

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Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta.
Yun Bai, Marco Pontoglio, Thomas Hiesberger, Angus M Sinclair, Peter Igarashi

Am J Physiol Renal Physiol· October 2002

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A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP.
François Boudreau, Edmond H H M Rings, Gary P Swain, Angus M Sinclair, Eun Ran Suh

Mol Cell Biol· August 2002

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Rescue of the lethal scl(-/-) phenotype by the human SCL locus.
Angus M Sinclair, Anthony J Bench, Adrian J C Bloor, Juan Li, Berthold Göttgens

Blood· June 2002

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Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci.
Berthold Göttgens, Linda M Barton, Michael A Chapman, Angus M Sinclair, Bjarne Knudsen

Genome Res· May 2002

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