Publications by authors named "Anke Nijhuis"

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RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination.
Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Anke M Nijhuis

Commun Biol· December 2025

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Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn's Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets.
Amy Lewis, David T Humphreys, Belen Pan-Castillo, Giulio Berti, Carla Felice, Anke Nijhuis

J Crohns Colitis· June 2024

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RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and metabolic reprogramming in cancer.
Hector C Keun, Anke Nijhuis

Mol Cell· December 2023

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Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma.
Yuewei Xu, Sarah Spear, Yurui Ma, Marc P Lorentzen, Michael Gruet, Anke Nijhuis

Cell Rep· October 2023

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Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease.
Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis

Clin Sci (Lond)· October 2022

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RNA-binding motif protein 39 (RBM39): An emerging cancer target.
Yuewei Xu, Anke Nijhuis, Hector C Keun

Br J Pharmacol· June 2022

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Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.
Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells

Nat Commun· March 2022

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Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.
Emily M E Barnes, Yitao Xu, Adrian Benito, Lili Herendi, Alexandros P Siskos, Anke Nijhuis

Br J Cancer· April 2020

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Epithelial down-regulation of the miR-200 family in fibrostenosing Crohn's disease is associated with features of epithelial to mesenchymal transition.
Shameer J Mehta, Amy Lewis, Anke Nijhuis, Rosemary Jeffery, Paolo Biancheri

J Cell Mol Med· November 2018

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GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions.
Viviana Bustos, Áine M Nolan, Anke Nijhuis, Harry Harvey, Alexandra Parker

Oncotarget· October 2017

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MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8.
Anke Nijhuis, Renata Curciarello, Shameer Mehta, Roger Feakins, Cleo L Bishop

Cell Tissue Res· May 2017

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Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance.
Anke Nijhuis, Hannah Thompson, Julie Adam, Alexandra Parker, Luke Gammon

Hum Mol Genet· April 2017

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Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer.
Valeria Santoro, Ruochen Jia, Hannah Thompson, Anke Nijhuis, Rosemary Jeffery

J Natl Cancer Inst· June 2016

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Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn's Disease Phenotype.
Amy Lewis, Shameer Mehta, Luke N Hanna, Laura A Rogalski, Rosemary Jeffery, Anke Nijhuis

Inflamm Bowel Dis· August 2015

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Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease.
Shameer Mehta, Anke Nijhuis, Tomoko Kumagai, James Lindsay, Andrew Silver

Cell Tissue Res· June 2015

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Intestinal fibrosis in Crohn's disease: role of microRNAs as fibrogenic modulators, serum biomarkers, and therapeutic targets.
Amy Lewis, Anke Nijhuis, Shameer Mehta, Tomoko Kumagai, Roger Feakins

Inflamm Bowel Dis· May 2015

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In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts.
Anke Nijhuis, Paolo Biancheri, Amy Lewis, Cleo L Bishop, Paolo Giuffrida

Clin Sci (Lond)· September 2014

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DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.
Tammie S MacFie, Richard Poulsom, Alexandra Parker, Gary Warnes, Tatjana Boitsova, Anke Nijhuis

Inflamm Bowel Dis· March 2014

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