Publications by authors named "Ann Greer"

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Paradoxes of professional autonomy: a qualitative study of U.S. neonatologists from 1978-2017.
Michael D Rozier, Charley E Willison, Renee R Anspach, Joel D Howell, Ann L Greer, Scott L Greer

Sociol Health Illn· November 2020

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The determinants of medical technology adoption in different decisional systems: A systematic literature review.
Yauheniya Varabyova, Carl Rudolf Blankart, Ann Lennarson Greer, Jonas Schreyögg

Health Policy· March 2017

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IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.
Fei Huang, Han Chang, Ann Greer, Stephen Hillerman, Karen A Reeves

Mol Cancer Ther· February 2015

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Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Petra Ross-Macdonald, Heshani de Silva, Vishal Patel, Amy Truong, Aiqing He, Ann Greer

Bioorg Med Chem· March 2012

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Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
Xiaonan Hou, Fei Huang, Luciana F Macedo, Sean C Harrington, Karen A Reeves, Ann Greer

Cancer Res· December 2011

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Nonurgent emergency-department care: analysis of parent and primary physician perspectives.
David C Brousseau, Mark R Nimmer, Nichole L Yunk, Ann B Nattinger, Ann Greer

Pediatrics· February 2011

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Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.
Anthony J Sampognaro, Mark D Wittman, Joan M Carboni, Chiehying Chang, Ann F Greer

Bioorg Med Chem Lett· September 2010

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Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.
Fei Huang, Warren Hurlburt, Ann Greer, Karen A Reeves, Stephen Hillerman

Cancer Res· September 2010

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Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Upender Velaparthi, Mark G Saulnier, Mark D Wittman, Peiying Liu, David B Frennesson, Ann Greer

Bioorg Med Chem Lett· May 2010

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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
Kurt Zimmermann, Mark D Wittman, Mark G Saulnier, Upender Velaparthi, Xiaopeng Sang, Ann F Greer

Bioorg Med Chem Lett· March 2010

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Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
Mark D Wittman, Joan M Carboni, Zheng Yang, Francis Y Lee, Melissa Antman, Ann Greer

J Med Chem· December 2009

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.
Joan M Carboni, Mark Wittman, Zheng Yang, Francis Lee, Ann Greer

Mol Cancer Ther· December 2009

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The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors.
Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi

Cancer Res· January 2009

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Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.
Upender Velaparthi, Mark Wittman, Peiying Liu, Joan M Carboni, Francis Y Lee, Ann Greer

J Med Chem· October 2008

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Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.
Kurt Zimmermann, Mark D Wittman, Mark G Saulnier, Upender Velaparthi, David R Langley, Ann Greer

Bioorg Med Chem Lett· July 2008

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2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.
Mark G Saulnier, David B Frennesson, Mark D Wittman, Kurt Zimmermann, Upender Velaparthi, Ann Greer

Bioorg Med Chem Lett· March 2008

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Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.
Upender Velaparthi, Peiying Liu, Balu Balasubramanian, Joan Carboni, Ricardo Attar, Ann Greer

Bioorg Med Chem Lett· June 2007

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Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).
Upender Velaparthi, Mark Wittman, Peiying Liu, Karen Stoffan, Kurt Zimmermann, Ann Greer

Bioorg Med Chem Lett· April 2007

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Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
Mark D Wittman, Balu Balasubramanian, Karen Stoffan, Upender Velaparthi, Pieying Liu, Ann Greer

Bioorg Med Chem Lett· February 2007

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Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
Mark Wittman, Joan Carboni, Ricardo Attar, Balu Balasubramanian, Praveen Balimane, Ann Greer

J Med Chem· September 2005

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.
Joan M Carboni, Adrian V Lee, Darryl L Hadsell, Bruce R Rowley, Francis Y Lee, Ann F Greer

Cancer Res· May 2005

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Implementing evidence-based practice: evaluation of an opinion leader strategy to improve breast-feeding rates.
Jane E Sisk, Ann Lennarson Greer, Martha Wojtowycz, Lani B Pincus, Richard H Aubry

Am J Obstet Gynecol· February 2004

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Bringing the patient back in. Guidelines, practice variations, and the social context of medical practice.
Ann Lennarson Greer, James S Goodwin, Jean L Freeman, Z Helen Wu

Int J Technol Assess Health Care· March 2003

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Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption.
Mary Ann Gilligan, Ronald T Kneusel, Raymond G Hoffmann, Ann L Greer, Ann B Nattinger

Med Care· March 2002

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