Publications by authors named "Anna P Lam"

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Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease.
Nikolay S Markov, Anthony J Esposito, Karolina J Senkow, Maxwell Schleck, Luisa Cusick, Anna P Lam

bioRxiv· October 2025

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Safety and efficacy of vanzacaftor-tezacaftor-deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials.
Ahmet Z Uluer, Gordon MacGregor, Pilar Azevedo, Veronica Indihar, Claire Keating, Anna P Lam

Lancet Respir Med· June 2023

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A Novel MIP-1-Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers.
Paul A Reyfman, Elizabeth S Malsin, Basil Khuder, Nikita Joshi, Gaurav Gadhvi, Anna P Lam

Am J Respir Cell Mol Biol· February 2023

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Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.
Sivagurunathan Sutharsan, Edward F McKone, Damian G Downey, Jamie Duckers, Gordon MacGregor, Anna P Lam

Lancet Respir Med· March 2022

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Macrophages as a Source and Recipient of Wnt Signals.
Elizabeth S Malsin, Seokjo Kim, Anna P Lam, Cara J Gottardi

Front Immunol· September 2020

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The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Paul Cheresh, Seok-Jo Kim, Long Shuang Huang, Satoshi Watanabe, Nikita Joshi, Anna P Lam

Int J Mol Sci· August 2020

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Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Seok-Jo Kim, Paul Cheresh, Renea P Jablonski, Lyudmila Rachek, Anjana Yeldandi, Anna P Lam

Am J Physiol Lung Cell Mol Physiol· May 2020

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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Paul A Reyfman, James M Walter, Nikita Joshi, Kishore R Anekalla, Alexandra C McQuattie-Pimentel, Anna P Lam

Am J Respir Crit Care Med· June 2019

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Respiratory dysfunction following initiation of mirabegron: A case report.
Elizabeth S Malsin, John M Coleman, Lisa F Wolfe, Anna P Lam

Respir Med Case Rep· February 2019

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A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells.
Annette S Flozak, Anna P Lam, Cara J Gottardi

Methods Mol Biol· January 2018

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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Alexander V Misharin, Luisa Morales-Nebreda, Paul A Reyfman, Carla M Cuda, James M Walter, Anna P Lam

J Exp Med· August 2017

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Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.
Joseph A Sennello, Alexander V Misharin, Annette S Flozak, Sergejs Berdnikovs, Paul Cheresh, Anna P Lam

Am J Respir Cell Mol Biol· February 2017

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Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.
Lauren Reinke, Anna P Lam, Annette S Flozak, John Varga, Cara J Gottardi

Biochem Biophys Res Commun· February 2016

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Vimentin regulates activation of the NLRP3 inflammasome.
Gimena dos Santos, Micah R Rogel, Margaret A Baker, James R Troken, Daniela Urich, Anna P Lam

Nat Commun· March 2015

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Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.
Anna P Lam, Jose D Herazo-Maya, Joseph A Sennello, Annette S Flozak, Susan Russell

Am J Respir Crit Care Med· July 2014

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Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response.
David W Kamp, Gang Liu, Paul Cheresh, Seok-Jo Kim, Amanda Mueller, Anna P Lam

Am J Respir Cell Mol Biol· December 2013

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Fat in fibrosis.
Anna P Lam, Cara J Gottardi

Am J Respir Crit Care Med· November 2013

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Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.
Jun Wei, Feng Fang, Anna P Lam, Jennifer L Sargent, Emily Hamburg

Arthritis Rheum· August 2012

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Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.
Gökhan M Mutlu, G R Scott Budinger, Minghua Wu, Anna P Lam, Aaron Zirk

Thorax· February 2012

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Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
Anna P Lam, Annette S Flozak, Susan Russell, Jun Wei, Manu Jain

Am J Respir Cell Mol Biol· November 2011

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β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target.
Anna P Lam, Cara J Gottardi

Curr Opin Rheumatol· November 2011

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Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
Jun Wei, Denisa Melichian, Kazuhiro Komura, Monique Hinchcliff, Anna P Lam

Arthritis Rheum· June 2011

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Regenerative pathways and emphysema: a new paradigm?
Anna P Lam, Cara J Gottardi, Rubin Tuder

Am J Respir Crit Care Med· March 2011

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Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Annette S Flozak, Anna P Lam, Susan Russell, Manu Jain, Ofra N Peled

J Biol Chem· January 2010

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Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis.
Lisa R Young, David N Franz, Preeti Nagarkatte, Christopher D M Fletcher, Kathryn A Wikenheiser-Brokamp, Anna P Lam

Chest· September 2009

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