Publications by authors named "Anna Szlachcic"

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Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC.
Przemysław Glaza, Roman Pluta, Krzysztofa E Odrzywół, Marta Klejnot, Maria Wieczorek, Anna Szlachcic

Commun Chem· August 2025

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Fibroblast Growth Factors in Lung Development and Regeneration: Mechanisms and Therapeutic Potential.
Karolina Baran, Kamila Skrzynska, Aleksandra A Czyrek, Adrianna Wittek, Daniel Krowarsch, Anna Szlachcic

Cells· August 2025

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Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies.
Karolina Jendryczko, Jakub Rzeszotko, Mateusz Adam Krzyscik, Anna Kocyła, Jakub Szymczyk, Anna Szlachcic

Mol Pharm· May 2022

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Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent.
Karolina Jendryczko, Jakub Rzeszotko, Mateusz Adam Krzyscik, Jakub Szymczyk, Jacek Otlewski, Anna Szlachcic

Front Pharmacol· November 2021

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Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation.
Mateusz Adam Krzyscik, Aleksandra Sokolowska-Wedzina, Karolina Jendryczko, Marta Pozniak, Daria Nawrocka, Anna Szlachcic

J Vis Exp· January 2021

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FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1.
Karolina Jendryczko, Julia Chudzian, Natalia Skinder, Łukasz Opaliński, Jakub Rzeszótko, Anna Szlachcic

Cancers (Basel)· October 2020

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Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity.
Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch

Cells· August 2019

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Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection.
Magdalena Lipok, Anna Szlachcic, Kinga Kindela, Aleksandra Czyrek, Jacek Otlewski

FEBS Open Bio· May 2019

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Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity.
Julia Chudzian, Anna Szlachcic, Malgorzata Zakrzewska, Miroslawa Czub, Marcin Pustula

Int J Mol Sci· August 2018

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FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.
Karolina Weronika Świderska, Anna Szlachcic, Łukasz Opaliński, Małgorzata Zakrzewska, Jacek Otlewski

Int J Mol Sci· July 2018

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In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.
Janine Kirstein, Kristin Arnsburg, Annika Scior, Anna Szlachcic, D Lys Guilbride

Aging Cell· December 2017

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High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.
Michal Lobocki, Malgorzata Zakrzewska, Anna Szlachcic, Mateusz A Krzyscik, Aleksandra Sokolowska-Wedzina

Bioconjug Chem· July 2017

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Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.
Nadinath B Nillegoda, Antonia Stank, Duccio Malinverni, Niels Alberts, Anna Szlachcic

Elife· May 2017

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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy.
Anna Szlachcic, Malgorzata Zakrzewska, Michal Lobocki, Piotr Jakimowicz, Jacek Otlewski

Drug Des Devel Ther· April 2017

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Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.
Eva Kummer, Anna Szlachcic, Kamila B Franke, Sophia Ungelenk, Bernd Bukau

J Mol Biol· October 2016

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Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.
Xuechao Gao, Marta Carroni, Carmen Nussbaum-Krammer, Axel Mogk, Nadinath B Nillegoda, Anna Szlachcic

Mol Cell· September 2015

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Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
Nadinath B Nillegoda, Janine Kirstein, Anna Szlachcic, Mykhaylo Berynskyy, Antonia Stank

Nature· August 2015

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FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation.
Anna Szlachcic, Katarzyna Pala, Malgorzata Zakrzewska, Piotr Jakimowicz, Antoni Wiedlocha

Int J Nanomedicine· April 2013

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Longer action means better drug: tuning up protein therapeutics.
Anna Szlachcic, Malgorzata Zakrzewska, Jacek Otlewski

Biotechnol Adv· November 2011

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Tailoring small proteins towards biomedical applications.
Malgorzata Zakrzewska, Anna Szlachcic, Jacek Otlewski

Curr Pharm Biotechnol· November 2011

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Two pentadehydropeptides with different configurations of the DeltaPhe residues.
Maciej Makowski, Marek Lisowski, Anna Maciag, Maciej Wiktor, Anna Szlachcic

Acta Crystallogr C· March 2010

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Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
Malgorzata Zakrzewska, Antoni Wiedlocha, Anna Szlachcic, Daniel Krowarsch, Jacek Otlewski

J Biol Chem· September 2009

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The structural basis of tail-anchored membrane protein recognition by Get3.
Agnieszka Mateja, Anna Szlachcic, Maureen E Downing, Malgorzata Dobosz, Malaiyalam Mariappan

Nature· September 2009

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Structure of a highly stable mutant of human fibroblast growth factor 1.
Anna Szlachcic, Małgorzata Zakrzewska, Daniel Krowarsch, Vibeke Os, Ronny Helland

Acta Crystallogr D Biol Crystallogr· January 2009

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