Publications by authors named "Annabelle Varrot"

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The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA.
Steffen Leusmann, Eike Siebs, Sakonwan Kuhaudomlarp, Annabelle Varrot, Anne Imberty

Angew Chem Int Ed Engl· December 2025

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A novel SadP-scFv UCHT1 lectibody activates T cells and mediates lysis of Burkitt's lymphoma cells.
Jana Tomisch, Jonas Gräber, Olga N Makshakova, Pavel Salavei, Francesca Rosato, Annabelle Varrot

RSC Chem Biol· November 2025

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Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight - Infections: A Biophysical Study.
Giulia Antonini, Mario Fares, Dirk Hauck, Patrycja Mała, Emilie Gillon, Annabelle Varrot

J Med Chem· May 2025

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Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands.
Giulia Antonini, Anna Bernardi, Emilie Gillon, Alberto Dal Corso, Monica Civera, Annabelle Varrot

J Med Chem· November 2024

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Bioinformatic, Enzymatic, and Structural Characterization of Hexosaminidase HEX-2.
Zuzanna Dutkiewicz, Annabelle Varrot, Karen J Breese, Keith A Stubbs, Lena Nuschy

Biochemistry· August 2024

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Elucidating the glycan-binding specificity and structure of agglutinin, a new R-type lectin.
Jon Lundstrøm, Emilie Gillon, Valérie Chazalet, Nicole Kerekes, Antonio Di Maio, Annabelle Varrot

Beilstein J Org Chem· February 2024

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Cell-free expression and characterization of multivalent rhamnose-binding lectins using bio-layer interferometry.
Katherine F Warfel, Eugénie Laigre, Sarah E Sobol, Emilie Gillon, Annabelle Varrot

Glycobiology· June 2023

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Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations.
Giulia Antonini, Monica Civera, Kanhaya Lal, Sarah Mazzotta, Annabelle Varrot

Front Mol Biosci· May 2023

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Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties.
Alexandre Bruneau, Emilie Gillon, Aurélie Furiga, Etienne Brachet, Mouad Alami, Annabelle Varrot

Eur J Med Chem· February 2023

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Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from .
Sarah Mazzotta, Giulia Antonini, Francesca Vasile, Emilie Gillon, Jon Lundstrøm, Annabelle Varrot

Molecules· February 2023

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Multivalent Fucosides Targeting β-Propeller Lectins from Lung Pathogens with Promising Anti-Adhesive Properties.
Margherita Duca, Diksha Haksar, Jacq van Neer, Dominique M E Thies-Weesie, Dania Martínez-Alarcón, Annabelle Varrot

ACS Chem Biol· December 2022

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Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of 's BC2L-C Lectin.
Rafael Bermeo, Kanhaya Lal, Davide Ruggeri, Daniele Lanaro, Sarah Mazzotta, Annabelle Varrot

ACS Chem Biol· October 2022

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Discovery of -β-l-Fucosyl Amides as High-Affinity Ligands for the Lectin LecB.
Patrycja Mała, Eike Siebs, Joscha Meiers, Katharina Rox, Annabelle Varrot

J Med Chem· October 2022

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The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.
Simona Notova, François Bonnardel, Francesca Rosato, Lina Siukstaite, Jessica Schwaiger, Annabelle Varrot

Commun Biol· September 2022

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Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity.
Silvia Bleuler-Martinez, Annabelle Varrot, Vincent Olieric, Mario Schubert, Eva Vogt

Glycobiology· June 2022

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Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc.
Dani Zalem, Martin Juhás, Manuela Terrinoni, Natalie King-Lyons, Michael Lebens, Annabelle Varrot

Glycobiology· April 2022

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Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum.
Dania Martínez-Alarcón, Viviane Balloy, Jean-Philippe Bouchara, Roland J Pieters, Annabelle Varrot

Sci Rep· August 2021

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Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*.
Kanhaya Lal, Rafael Bermeo, Jonathan Cramer, Francesca Vasile, Beat Ernst, Annabelle Varrot

Chemistry· July 2021

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Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins.
Sakonwan Kuhaudomlarp, Eike Siebs, Elena Shanina, Jérémie Topin, Ines Joachim, Annabelle Varrot

Angew Chem Int Ed Engl· April 2021

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Hexavalent thiofucosides to probe the role of the Aspergillus fumigatus lectin FleA in fungal pathogenicity.
Christophe Dussouy, Pierre-Alban Lalys, Aurore Cabanettes, Victor Lehot, David Deniaud, Annabelle Varrot

Org Biomol Chem· April 2021

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LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa.
Sakonwan Kuhaudomlarp, Emilie Gillon, Annabelle Varrot, Anne Imberty

Methods Mol Biol· March 2021

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Expression, Purification, and Applications of the Recombinant Lectin PVL from Psathyrella velutina Specific for Terminal N-Acetyl-Glucosamine.
Oriane Machon, Annabelle Varrot

Methods Mol Biol· March 2021

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LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
Emilie Gillon, Annabelle Varrot, Anne Imberty

Methods Mol Biol· March 2021

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Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans.
Therese Wohlschlager, Alexander Titz, Markus Künzler, Annabelle Varrot

Methods Mol Biol· March 2021

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Recombinant Lectin from Tepary Bean () with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification.
Dania Martínez-Alarcón, Annabelle Varrot, Elaine Fitches, John A Gatehouse, Min Cao

Biomolecules· April 2020

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