Publications by authors named "Anne Hakem"

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DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Mitra Shokrollahi, Mia Stanic, Anisha Hundal, Janet N Y Chan, Defne Urman, Anne Hakem, Razqallah Hakem

Nat Struct Mol Biol· September 2024

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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity.
Erin Sellars, Margarita Savguira, Jie Wu, Sabrina Cancelliere, Mark Jen, Anne Hakem, Razqallah Hakem

iScience· July 2024

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Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Cynthia T Luk, Carmen K Chan, Felix Chiu, Sally Yu Shi, Paraish S Misra, Anne Hakem, Razqallah Hakem

Diabetes· December 2023

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RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, Kevin C J Nixon, Samah El Ghamrasni, Anne Hakem, Razqallah Hakem

Nucleic Acids Res· October 2023

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Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.
Parasvi S Patel, Arash Algouneh, Rehna Krishnan, John J Reynolds, Kevin C J Nixon, Anne Hakem, Razqallah Hakem

Nucleic Acids Res· May 2023

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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
Li Li, Kiran Kumar Naidu Guturi, Brandon Gautreau, Parasvi S Patel, Amine Saad, Anne Hakem, Razq Hakem

J Clin Invest· July 2021

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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Parasvi S Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, Marie-Jo Halaby, Zahra Khan, Anne Hakem, Razqallah Hakem

J Clin Invest· February 2021

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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
Li Li, Kiran Kumar Naidu Guturi, Brandon Gautreau, Parasvi S Patel, Amine Saad, Anne Hakem, Razq Hakem

J Clin Invest· October 2018

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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.
Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Anne Hakem, Razqallah Hakem

Nat Commun· August 2016

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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
Miyuki Bohgaki, Toshiyuki Bohgaki, Samah El Ghamrasni, Tharan Srikumar, Georges Maire, Anne Hakem, Razqallah Hakem

Proc Natl Acad Sci U S A· December 2013

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Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation.
Marie-jo Halaby, Razqallah Hakem, Anne Hakem

Cell Cycle· September 2013

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Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.
Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Razqallah Hakem

PLoS Genet· May 2013

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Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.
Anne Hakem, Samah El Ghamrasni, Georges Maire, Benedicte Lemmers, Jana Karaskova, Razqallah Hakem

Blood· April 2012

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Role of Pirh2 in mediating the regulation of p53 and c-Myc.
Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Razqallah Hakem

PLoS Genet· November 2011

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Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis.
Yong-Sam Jung, Anne Hakem, Razqallah Hakem, Xinbin Chen

Mol Cell Biol· October 2011

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Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.
Toshiyuki Bohgaki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Anne Hakem, Razqallah Hakem

J Cell Biol· October 2011

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Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
Samah El Ghamrasni, Ashwin Pamidi, Marie Jo Halaby, Miyuki Bohgaki, Renato Cardoso, Anne Hakem, Razqallah Hakem

PLoS Genet· May 2011

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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Anne Hakem, Razqallah Hakem

PLoS Genet· April 2011

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Dysregulation of the mevalonate pathway promotes transformation.
James W Clendening, Aleks Pandyra, Paul C Boutros, Samah El Ghamrasni, Fereshteh Khosravi, Anne Hakem, Razqallah Hakem

Proc Natl Acad Sci U S A· August 2010

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Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
Li Li, Marie-Jo Halaby, Anne Hakem, Renato Cardoso, Samah El Ghamrasni, Razqallah Hakem

J Exp Med· May 2010

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Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Ashwin Pamidi, Renato Cardoso, Anne Hakem, Elzbieta Matysiak-Zablocki, Anuradha Poonepalli, Razqallah Hakem

Cancer Res· September 2007

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Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.
Bénédicte Lemmers, Leonardo Salmena, Nicolas Bidère, Helen Su, Elzbieta Matysiak-Zablocki, Razqallah Hakem, Anne Hakem

J Biol Chem· March 2007

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Anne Hakem, Otto Sanchez-Sweatman, Annick You-Ten, Gordon Duncan, Andrew Wakeham

Genes Dev· September 2005

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
John Peter McPherson, Laura Tamblyn, Andrew Elia, Eva Migon, Amro Shehabeldin, Anne Hakem, Razqallah Hakem

EMBO J· September 2004

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Collaboration of Brca1 and Chk2 in tumorigenesis.
John Peter McPherson, Bénédicte Lemmers, Atsushi Hirao, Anne Hakem, Jacinth Abraham, Razqallah Hakem

Genes Dev· May 2004

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