Publications by authors named "April Averill"

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Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair.
Yuzhen Li, Mark Returan, Adele T Guerin, April M Averill, Dorcas Oladapo

Proc Natl Acad Sci U S A· November 2025

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Dynamic stem-loop extension by Pol θ and templated insertion during DNA repair.
Denisse Carvajal-Maldonado, Yuzhen Li, Mark Returan, April M Averill, Sylvie Doublié

J Biol Chem· July 2024

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Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters.
Camilla A Strother, Paul D Brewer-Jensen, Sylvia Becker-Dreps, Omar Zepeda, Samantha May, April M Averill

Front Immunol· September 2023

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Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.
Brian E Eckenroth, Vy Bao Cao, April M Averill, Julie A Dragon, Sylvie Doublié

Structure· January 2021

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Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2-Amino Group of 8-Oxoguanine.
Andrea J Lee, Chandrima Majumdar, Scott D Kathe, Robert P Van Ostrand, Holly R Vickery, April M Averill

J Am Chem Soc· August 2020

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Inhibition of the chimeric DnaJ-PKAc enzyme by endogenous inhibitor proteins.
April M Averill, Hibba Tul Rehman, Joseph W Charles, Timothy A Dinh, Karamatullah Danyal

J Cell Biochem· August 2019

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Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant.
Shane R Nelson, Scott D Kathe, Thomas S Hilzinger, April M Averill, David M Warshaw

Nucleic Acids Res· April 2019

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Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.
Michelle C Silva, Katie E Bryan, Milagros D Morrical, April M Averill, Julie Dragon

DNA Repair (Amst)· December 2017

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The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ.
Daniel J Laverty, April M Averill, Sylvie Doublié, Marc M Greenberg

ACS Chem Biol· June 2017

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RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
Michelle C Silva, Milagros D Morrical, Katie E Bryan, April M Averill, Julie Dragon

DNA Repair (Amst)· June 2016

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The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures.
Jia Zhou, Aaron M Fleming, April M Averill, Cynthia J Burrows, Susan S Wallace

Nucleic Acids Res· August 2015

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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.
Karl E Zahn, April M Averill, Pierre Aller, Richard D Wood, Sylvie Doublié

Nat Struct Mol Biol· April 2015

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The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures.
Jia Zhou, Aaron M Fleming, April M Averill, Cynthia J Burrows, Susan S Wallace

Nucleic Acids Res· April 2015

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Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Jianhong Chen, Milagros D Morrical, Katherine A Donigan, Joanne B Weidhaas, Joann B Sweasy, April M Averill

Nucleic Acids Res· January 2015

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Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.
Aishwarya Prakash, Brian E Eckenroth, April M Averill, Kayo Imamura, Susan S Wallace

DNA Repair (Amst)· December 2013

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Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.
Minmin Liu, Kayo Imamura, April M Averill, Susan S Wallace, Sylvie Doublié

Structure· February 2013

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Expression and purification of active mouse and human NEIL3 proteins.
Minmin Liu, Viswanath Bandaru, Alicia Holmes, April M Averill, Wendy Cannan

Protein Expr Purif· July 2012

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Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.
Kayo Imamura, April Averill, Susan S Wallace, Sylvie Doublié

J Biol Chem· February 2012

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The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site.
Karl E Zahn, April Averill, Susan S Wallace, Sylvie Doublié

Biochemistry· November 2011

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
Yuefen Zhou, Lian-Sheng Li, Peter S Dragovich, Douglas E Murphy, Chinh V Tran, April Averill

Bioorg Med Chem Lett· February 2008

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Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods.
Peggy A Thompson, Shaohui Wang, Lindsay J Howett, Mei-Mei Wang, Rupal Patel, April Averill

Assay Drug Dev Technol· February 2008

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Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities.
Zhe Nie, Carin Perretta, Philip Erickson, Stephen Margosiak, Jia Lu, April Averill

Bioorg Med Chem Lett· January 2008

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Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.
Zhe Nie, Carin Perretta, Philip Erickson, Stephen Margosiak, Robert Almassy, April Averill

Bioorg Med Chem Lett· August 2007

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