Publications by authors named "April Hartley"

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Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank.
Andrew R Elmore, Nimish Adhikari, April E Hartley, Hugo Javier Aparicio, Daniel C Posner

Stroke· August 2024

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Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: A Mendelian randomisation investigation.
Maria K Sobczyk, Benjamin G Faber, Lorraine Southam, Monika Frysz, April Hartley

Osteoarthritis Cartilage· June 2024

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Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank.
Andrew Elmore, Nimish Adhikari, April E Hartley, Hugo Javier Aparicio, Dan C Posner

medRxiv· February 2024

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Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.
Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F M Andlauer, Michelle S Yau, April E Hartley

Arthritis Rheumatol· October 2023

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The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.
Benjamin G Faber, Monika Frysz, Cindy G Boer, Daniel S Evans, Raja Ebsim, April Hartley

EBioMedicine· September 2023

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Genetic underpinning of the comorbidity between type 2 diabetes and osteoarthritis.
Ana Luiza Arruda, April Hartley, Georgia Katsoula, George Davey Smith, Andrew P Morris

Am J Hum Genet· August 2023

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Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study.
Grace Marion Power, Jonathan H Tobias, Timothy M Frayling, Jessica Tyrrell, April E Hartley

Eur J Epidemiol· July 2023

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A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.
Benjamin G Faber, Monika Frysz, April E Hartley, Raja Ebsim, Cindy G Boer

Arthritis Rheumatol· June 2023

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Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression.
Ruth E Mitchell, April E Hartley, Venexia M Walker, Apostolos Gkatzionis, James Yarmolinsky

PLoS Genet· February 2023

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A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field.
April E Hartley, Grace M Power, Eleanor Sanderson, George Davey Smith

JBMR Plus· October 2022

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index.
April Hartley, Eleanor Sanderson, Raquel Granell, Lavinia Paternoster, Jie Zheng

Int J Epidemiol· August 2022

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Adjusting for collider bias in genetic association studies using instrumental variable methods.
Siyang Cai, April Hartley, Osama Mahmoud, Kate Tilling, Frank Dudbridge

Genet Epidemiol· July 2022

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, April Hartley

Cell· November 2021

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, April Hartley

Cell· September 2021

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Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis.
April Hartley, Eleanor Sanderson, Lavinia Paternoster, Alexander Teumer, Robert C Kaplan

Rheumatology (Oxford)· April 2021

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Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.
Diana L Cousminer, Yadav Wagley, James A Pippin, Ahmed Elhakeem, Gregory P Way, April Hartley

Genome Biol· January 2021

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Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study.
April Hartley, Sarah A Hardcastle, Monika Frysz, Jon Parkinson, Lavinia Paternoster

Arthritis Res Ther· January 2021

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A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis.
Celia L Gregson, Dylan J M Bergen, Paul Leo, Richard B Sessions, Lawrie Wheeler, April Hartley

J Bone Miner Res· January 2020

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Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population.
April Hartley, Lavinia Paternoster, David M Evans, William D Fraser, Jonathan Tang

Clin Endocrinol (Oxf)· January 2020

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Metabolic profiling of adolescent non-alcoholic fatty liver disease.
April Hartley, Diana L Santos Ferreira, Emma L Anderson, Debbie A Lawlor

Wellcome Open Res· September 2019

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Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe.
Celia L Gregson, April Hartley, Edith Majonga, Grace McHugh, Nicola Crabtree

Bone· August 2019

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Correlates of high-impact physical activity measured objectively in older British adults.
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark

J Public Health (Oxf)· December 2018

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Physical Activity Producing Low, but Not Medium or Higher, Vertical Impacts Is Inversely Related to BMI in Older Adults: Findings From a Multicohort Study.
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark

J Gerontol A Biol Sci Med Sci· April 2018

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Sarcopenia Is Negatively Related to High Gravitational Impacts Achieved From Day-to-day Physical Activity.
April Hartley, Celia L Gregson, Kimberly Hannam, Kevin C Deere, Emma M Clark

J Gerontol A Biol Sci Med Sci· April 2018

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Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life.
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark

Prev Med Rep· December 2017

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