Publications by authors named "Araya Umetsu"

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Treatment with pemafibrate ameliorates fatty liver index and atherogenic lipid profiles in Japanese patients with type 2 diabetes mellitus.
Toru Suzuki, Tatsuya Sato, Marenao Tanaka, Kei Nakata, Keisuke Endo, Araya Umetsu

Front Endocrinol (Lausanne)· August 2025

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A silent interplay between elevated intraocular pressure, glaucoma, and hypertension.
Tatsuya Sato, Araya Umetsu, Marenao Tanaka, Hiroshi Ohguro, Masato Furuhashi

Hypertens Res· March 2025

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The Combination of PPARα Agonist GW7647 and Imeglimin Has Potent Effects on High-Glucose-Induced Cellular Biological Responses in Human Retinal Pigment Epithelium Cells.
Nami Nishikiori, Megumi Watanabe, Megumi Higashide, Araya Umetsu, Toshifumi Ogawa

Bioengineering (Basel)· March 2025

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Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts.
Megumi Watanabe, Yuri Tsugeno, Tatsuya Sato, Megumi Higashide, Araya Umetsu

Graefes Arch Clin Exp Ophthalmol· January 2025

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Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts.
Fumihito Hikage, Megumi Suzuki, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa

Sci Rep· January 2025

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Correction: Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts.
Megumi Watanabe, Yuri Tsugeno, Tatsuya Sato, Megumi Higashide, Araya Umetsu

Graefes Arch Clin Exp Ophthalmol· December 2024

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TGF-β effects on adipogenesis of 3T3-L1 cells differ in 2D and 3D cell culture conditions.
Araya Umetsu, Megumi Watanabe, Tatsuya Sato, Megumi Higashide, Nami Nishikiori

FEBS Open Bio· December 2024

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RHO-Associated Coiled-Coil-Containing Protein Kinase Inhibitors Significantly Modulate the Epithelial-Mesenchymal Transition Induced by TGF-β2 in the 2-D and 3-D Cultures of Human Corneal Stroma Fibroblasts.
Araya Umetsu, Yosuke Ida, Tatsuya Sato, Megumi Higashide, Nami Nishikiori

Biomedicines· December 2024

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High Intraocular Pressure Is Independently Associated With New-Onset Systemic Hypertension Over a 10-Year Period.
Araya Umetsu, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo

Circ J· September 2024

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Application of Single Cell Type-Derived Spheroids Generated by Using a Hanging Drop Culture Technique in Various Disease Models: A Narrow Review.
Hiroshi Ohguro, Megumi Watanabe, Tatsuya Sato, Nami Nishikiori, Araya Umetsu

Cells· September 2024

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Unexpected and Synergistical Effects of All-Trans Retinoic Acid and TGF-β2 on Biological Aspects of 2D and 3D Cultured ARPE19 Cells.
Megumi Higashide, Megumi Watanabe, Tatsuya Sato, Toshifumi Ogawa, Araya Umetsu

Biomedicines· September 2024

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Metabolic dysfunction-associated steatotic liver disease (SLD) and alcohol-associated liver disease, but not SLD without metabolic dysfunction, are independently associated with new onset of chronic kidney disease during a 10-year follow-up period.
Kazuma Mori, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo, Araya Umetsu

Hepatol Res· August 2024

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FABP5 Is a Possible Factor for the Maintenance of Functions of Human Non-Pigmented Ciliary Epithelium Cells.
Megumi Higashide, Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Nami Nishikiori

Int J Mol Sci· August 2024

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Tirzepatide ameliorates eating behaviors regardless of prior exposure to glucagon-like peptide receptor agonists in Japanese patients with type 2 diabetes mellitus.
Toru Suzuki, Tatsuya Sato, Marenao Tanaka, Keisuke Endo, Kei Nakata, Araya Umetsu

J Diabetes Complications· July 2024

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Fatty Acid-Binding Protein 4-Mediated Regulation Is Pivotally Involved in Retinal Pathophysiology: A Review.
Hiroshi Ohguro, Megumi Watanabe, Fumihito Hikage, Tatsuya Sato, Nami Nishikiori, Araya Umetsu

Int J Mol Sci· July 2024

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Benzalkonium chloride greatly deteriorates the biological activities of human corneal stroma fibroblasts in a concentration-dependent manner.
Araya Umetsu, Yosuke Ida, Tatsuya Sato, Masato Furuhashi, Hiroshi Ohguro

Graefes Arch Clin Exp Ophthalmol· June 2024

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TGF-β Isoforms and Local Environments Greatly Modulate Biological Nature of Human Retinal Pigment Epithelium Cells.
Nami Nishikiori, Tatsuya Sato, Toshifumi Ogawa, Megumi Higashide, Araya Umetsu

Bioengineering (Basel)· June 2024

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FABP4 Is an Indispensable Factor for Regulating Cellular Metabolic Functions of the Human Retinal Choroid.
Hiroshi Ohguro, Megumi Watanabe, Tatsuya Sato, Nami Nishikiori, Araya Umetsu

Bioengineering (Basel)· June 2024

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Lysophosphatidic Acid Modulates TGF-β2-Induced Biological Phenotype in Human Conjunctival Fibroblasts.
Megumi Watanabe, Yuri Tsugeno, Tatsuya Sato, Megumi Higashide, Nami Nishikiori, Araya Umetsu

Life (Basel)· June 2024

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Modulation of Epithelial-Mesenchymal Transition Is a Possible Underlying Mechanism for Inducing Chemoresistance in MIA PaCa-2 Cells against Gemcitabine and Paclitaxel.
Hajime Nakamura, Megumi Watanabe, Kohichi Takada, Tatsuya Sato, Fumihito Hikage, Araya Umetsu

Biomedicines· May 2024

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The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells.
Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori

Biomedicines· May 2024

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Differential Effects of Benzalkonium Chloride on Human Trabecular Meshwork Cells Not Treated or Treated with Transforming Growth Factor-β2 or Dexamethasone.
Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Nami Nishikiori, Megumi Higashide

J Ocul Pharmacol Ther· April 2024

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Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier.
Nami Nishikiori, Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Megumi Higashide

Prostaglandins Leukot Essent Fatty Acids· March 2024

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Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs).
Hiroshi Ohguro, Araya Umetsu, Tatsuya Sato, Masato Furuhashi, Megumi Watanabe

Int J Mol Sci· December 2023

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3D culture induction of adipogenic differentiation in 3T3-L1 preadipocytes exhibits adipocyte-specific molecular expression patterns and metabolic functions.
Keisuke Endo, Tatsuya Sato, Araya Umetsu, Megumi Watanabe, Fumihito Hikage

Heliyon· October 2023

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