Publications by authors named "Ariel Silber"

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Energy metabolism in : the validated and putative bioenergetic and carbon sources.
Mayke B Alencar, Sabrina Marsiccobetre, Ana C Mengarda, Maria Sol Ballari, Ariel M Silber

mBio· June 2025

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Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of .
Janaína de Freitas Nascimento, María Julia Barisón, Gabriela Torres Montanaro, Letícia Marchese, Rodolpho Ornitz Oliveira Souza, Ariel Mariano Silber

Microb Cell· June 2025

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The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of .
Mayke Bezerra Alencar, Richard Marcel Bruno Moreira Girard, Marcell Crispim, Carlos Gustavo Baptista, Marc Biran, Ariel Mariano Silber

mSphere· March 2025

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Branched-chain amino acids modulate the proteomic profile of Trypanosoma cruzi metacyclogenesis induced by proline.
Janaina de Freitas Nascimento, Flávia Silva Damasceno, Sabrina Marsiccobetre, Francisca Natália de Luna Vitorino, Renan Weege Achjian, Ariel Mariano Silber

PLoS Negl Trop Dis· October 2024

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Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer's-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function.
Camila A E F Cardinali, Yandara A Martins, Ruan C M Moraes, Andressa P Costa, Mayke B Alencar, Ariel M Silber

ACS Chem Neurosci· August 2024

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Navigating the boundaries between metabolism and epigenetics in trypanosomes.
Ana Paula Menezes, Ana Milena Murillo, Camila Gachet de Castro, Natalia Karla Bellini, Luiz Ricardo Orsini Tosi, Ariel Mariano Silber

Trends Parasitol· August 2023

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Correction: How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell.
Janaina F Nascimento, Rodolpho O O Souza, Mayke B Alencar, Sabrina Marsiccobetre, Ana M Murillo, Ariel M Silber

PLoS Pathog· August 2023

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How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell.
Janaina F Nascimento, Rodolpho O O Souza, Mayke B Alencar, Sabrina Marsiccobetre, Ana M Murillo, Ariel M Silber

PLoS Pathog· July 2023

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Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.
Kate Sowerby, Stefanie Freitag-Pohl, Ana Milena Murillo, Ariel Mariano Silber, Ehmke Pohl

Acta Crystallogr D Struct Biol· June 2023

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Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis.
Denis Amilton Dos Santos, Higo Fernando Santos Souza, Ariel M Silber, Tatiana de Arruda Campos Brasil de Souza, Andréa Rodrigues Ávila

Front Cell Infect Microbiol· June 2023

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The TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
Mustafa M Aldfer, Ibrahim A Alfayez, Hamza A A Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ariel M Silber

Molecules· November 2022

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Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains.
Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber

PLoS One· August 2022

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Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci.
Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Bispo Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Ariel M Silber

Epigenetics Chromatin· July 2022

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Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci.
Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Ariel M Silber

Epigenetics Chromatin· June 2022

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Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector.
Brian S Mantilla, Lisvane Paes-Vieira, Felipe de Almeida Dias, Simone G Calderano, Maria Carolina Elias, Ariel M Silber

Biochem J· November 2021

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An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection.
Roberto I Cuevas-Hernández, Richard M B M Girard, Luka Krstulović, Miroslav Bajić, Ariel Mariano Silber

PLoS Negl Trop Dis· November 2021

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Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features.
Paul A M Michels, Oriana Villafraz, Erika Pineda, Mayke B Alencar, Ana J Cáceres, Ariel M Silber

Exp Parasitol· May 2021

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Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi.
Rodolpho Ornitz Oliveira Souza, Flávia Silva Damasceno, Sabrina Marsiccobetre, Marc Biran, Gilson Murata, Ariel Mariano Silber

PLoS Pathog· April 2021

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Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline.
Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Ariel M Silber

PLoS Pathog· March 2021

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Responsible Science Assessment: downplaying indexes, boosting quality.
Alicia J Kowaltowski, Ariel M Silber, Marcus F Oliveira

An Acad Bras Cienc· February 2021

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Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
Mariana Galvão Ferrarini, Lindice Mitie Nisimura, Richard Marcel Bruno Moreira Girard, Mayke Bezerra Alencar, Mariana Sayuri Ishikawa Fragoso, Ariel Mariano Silber

mSphere· January 2021

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Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms.
Alex R J Lima, Christiane B de Araujo, Saloe Bispo, José Patané, Ariel M Silber

PLoS Pathog· January 2021

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The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Fernanda C R de Paiva, Karen Chan, Markiyan Samborskyy, Ariel M Silber, Peter F Leadlay

Acta Crystallogr D Struct Biol· December 2020

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Abnormal sterol-induced cell wall glucan deficiency in yeast is due to impaired glucan synthase transport to the plasma membrane.
Roxana Gutierrez-Armijos, Rodrigo Antonio Ceschini Sussmann, Ariel Mariano Silber, Mauro Cortez, Agustin Hernandez

Biochem J· October 2020

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Targeting L-Proline Uptake as New Strategy for Anti-chagas Drug Development.
Lucía Fargnoli, Esteban A Panozzo-Zénere, Lucas Pagura, María Julia Barisón, Julia A Cricco, Ariel M Silber

Front Chem· August 2020

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