Publications by authors named "Peter F Leadlay"

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Efomycine U, a new -asymmetric elaiophylin derivative from DSM 4137.
Jing Xu, Jingwan Wu, Dongdong Zhou, Xuexia Zhang, Peter F Leadlay

Nat Prod Res· September 2024

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Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis.
Gabriel S de Oliveira, Priscila Dos S Bury, Fanglu Huang, Yuan Li, Natália C de Araújo, Peter F Leadlay

ACS Chem Biol· September 2024

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Glycodiversification of gentamicins through glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity.
Xinyun Jian, Cheng Wang, Shijuan Wu, Guo Sun, Chuan Huang, Peter F Leadlay

Acta Pharm Sin B· September 2024

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Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition.
Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Peter F Leadlay

Nat Commun· February 2023

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Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
Oksana Bilyk, Gabriel S Oliveira, Rafaela M de Angelo, Michell O Almeida, Kathia Maria Honório, Peter F Leadlay

J Am Chem Soc· August 2022

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Efophylins A and B, Two -Asymmetric Macrodiolide Immunosuppressants from .
Jing Xu, Xuexia Zhang, Fanglu Huang, Gang Li, Peter F Leadlay

J Nat Prod· May 2021

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Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase.
Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Peter F Leadlay

Angew Chem Int Ed Engl· December 2020

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The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Fernanda C R de Paiva, Karen Chan, Markiyan Samborskyy, Ariel M Silber, Peter F Leadlay

Acta Crystallogr D Struct Biol· December 2020

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The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic.
Rory F Little, Markiyan Samborskyy, Peter F Leadlay

PLoS One· November 2020

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Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase.
Yaoyao Shen, Fan Sun, Liu Zhang, Yijia Cheng, Hongrui Zhu, Peter F Leadlay

J Biol Chem· April 2020

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The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.
Oksana Bilyk, Markiyan Samborskyy, Peter F Leadlay

PLoS One· January 2020

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Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis.
Rory Little, Fernanda C R Paiva, Rob Jenkins, Hui Hong, Yuhui Sun, Peter F Leadlay

Nat Catal· October 2019

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Sarpeptins A and B, Lipopeptides Produced by sp. KO-7888 Overexpressing a Specific SARP Regulator.
Wilaiwan Koomsiri, Yuki Inahashi, Kantinan Leetanasaksakul, Kazuro Shiomi, Yo Ko Takahashi, Peter F Leadlay

J Nat Prod· August 2019

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Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase.
Matthias Häckh, Xavier Lucas, Marija Marolt, Peter F Leadlay, Michael Müller

Chembiochem· May 2019

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C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A.
Hui Hong, Markiyan Samborskyy, Yongjun Zhou, Peter F Leadlay

Cell Chem Biol· April 2019

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Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase.
Yongjun Zhou, Xiao Lin, Simon R Williams, Liyun Liu, Yaoyao Shen, Peter F Leadlay

ACS Chem Biol· August 2018

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Methyltransferases of gentamicin biosynthesis.
Sicong Li, Junhong Guo, Anna Reva, Fanglu Huang, Binbin Xiong, Peter F Leadlay

Proc Natl Acad Sci U S A· February 2018

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Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
Priscila Dos Santos Bury, Fanglu Huang, Sicong Li, Yuhui Sun, Peter F Leadlay

ACS Chem Biol· November 2017

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Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes.
Hui Hong, Markiyan Samborskyy, Katsiaryna Usachova, Katharina Schnatz, Peter F Leadlay

Beilstein J Org Chem· November 2017

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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Aleksandra Wlodek, Steve G Kendrew, Nigel J Coates, Adam Hold, Joanna Pogwizd, Peter F Leadlay

Nat Commun· October 2017

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An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain.
Wei Xu, Guifa Zhai, Yuanzhen Liu, Yuan Li, Yanrong Shi, Peter F Leadlay

Angew Chem Int Ed Engl· May 2017

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Isoafricanol synthase from Streptomyces malaysiensis.
Patrick Rabe, Markiyan Samborskyy, Peter F Leadlay, Jeroen S Dickschat

Org Biomol Chem· March 2017

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Chemical probing of thiotetronate bio-assembly.
Judith Havemann, Marie E Yurkovich, Robert Jenkins, Sophia Harringer, Weixin Tao, Peter F Leadlay

Chem Commun (Camb)· February 2017

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The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase.
Marie E Yurkovich, Robert Jenkins, Yuhui Sun, Manuela Tosin, Peter F Leadlay

Chem Commun (Camb)· February 2017

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Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase.
Hui Hong, Yuhui Sun, Yongjun Zhou, Emily Stephens, Markiyan Samborskyy, Peter F Leadlay

Beilstein J Org Chem· October 2016

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