Publications by authors named "Rory Little"

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Calcium-Dependent Lipopeptide Antibiotics against Drug-Resistant Pathogens Discovered via Host-Dependent Heterologous Expression of a Cloned Biosynthetic Gene Cluster.
Hung-En Lai, V Helen Woolner, Rory F Little, Ethan F Woolly, Robert A Keyzers

Angew Chem Int Ed Engl· November 2024

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Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds.
Rory F Little, Felix Trottmann, Hideki Hashizume, Miriam Preissler, Sandra Unger

ACS Chem Biol· March 2024

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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Rory F Little

Cell Chem Biol· December 2023

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Bacterial Pathogen Channels Medium-Sized Fatty Acids into Malleicyprol Biosynthesis.
Felix Trottmann, Jonas Fiedler, Keishi Ishida, Mie Ishida-Ito, Rory F Little

ACS Chem Biol· July 2023

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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Rory F Little

bioRxiv· March 2023

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An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor.
Rory Little, Felix Trottmann, Miriam Preissler, Christian Hertweck

RSC Chem Biol· August 2022

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Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.
Rory F Little, Christian Hertweck

Nat Prod Rep· January 2022

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Correction: Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.
Rory F Little, Christian Hertweck

Nat Prod Rep· January 2022

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Insect-Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non-Canonical Polyketide Chain Termination.
Sarah P Niehs, Jana Kumpfmüller, Benjamin Dose, Rory F Little, Keishi Ishida

Angew Chem Int Ed Engl· December 2020

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The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic.
Rory F Little, Markiyan Samborskyy, Peter F Leadlay

PLoS One· November 2020

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Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues.
Kelsi R Hall, Katherine J Robins, Elsie M Williams, Michelle H Rich, Mark J Calcott, Rory F Little

Elife· November 2020

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Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections.
Janine N Copp, Daniel Pletzer, Alistair S Brown, Joris Van der Heijden, Charlotte M Miton, Rory F Little

mBio· September 2020

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Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis.
Rory Little, Fernanda C R Paiva, Rob Jenkins, Hui Hong, Yuhui Sun

Nat Catal· October 2019

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Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Elsie M Williams, Rory F Little, Alexandra M Mowday, Michelle H Rich, Jasmine V E Chan-Hyams

Biochem J· October 2015

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