Publications by authors named "Arunkumar Manoharan"

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Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders.
Ramakrishna Nirogi, Venkata R Grandhi, Rajesh B Medapati, Narender Ganuga, Vijay Benade, Arunkumar Manoharan

J Psychopharmacol· June 2021

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The use of inactivated brain homogenate to determine the fraction unbound in brain for unstable compounds.
Ramakrishna Nirogi, Parusharamulu Molgara, Gopinadh Bhyrapuneni, Arunkumar Manoharan, Nagasurya Prakash Padala

Xenobiotica· October 2020

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Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (HR) inverse agonist in clinical development for the treatment of narcolepsy.
Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Nageswara Rao Muddana, Arunkumar Manoharan, Anil K Shinde

Eur J Pharm Sci· September 2020

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Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims.
Raghava Choudary Palacharla, Ramakrishna Nirogi, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni

Xenobiotica· July 2018

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Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats.
Vijay Benade, Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Saivishal Daripelli, Ganesh Ayyanki, Arunkumar Manoharan

Eur J Pharmacol· August 2017

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Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.
Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni, Nagasurya Prakash Padala

Eur J Pharm Sci· April 2017

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Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
Ramakrishna Nirogi, Raghava Choudary Palacharla, Abdul Rasheed Mohammed, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni

Chem Biol Interact· March 2015

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Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.
Ramakrishna Nirogi, Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Surya Rao Srikakolapu

Xenobiotica· February 2015

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Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes.
Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ranjith Kumar Ponnamaneni, Raghava choudary Palacharla, Arunkumar Manoharan

Drug Metab Dispos· November 2011

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